Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11494117 | 0.83 | CYP19A1 (0.56) | CYP19A1TSHRLMNAHTTMEN1 | |
| SCHEMBL7847044 | 0.81 | CYP3A4 (0.43) | CYP19A1TSHRLMNAMEN1KMT2A | |
| SCHEMBL5254416 | 0.80 | CYP19A1 (0.59) | CYP19A1TSHRLMNAHTTMEN1 | |
| SCHEMBL212845 | 0.79 | CYP19A1 (0.81) | CYP19A1TSHRLMNAHTTMEN1 | |
| SCHEMBL228816 | 0.79 | TSHR (0.67) | TSHRLMNAHTTMEN1KMT2A | |
| SCHEMBL30123489 | 0.79 | TSHR (0.67) | TSHRLMNAHTTMEN1KMT2A | |
| SCHEMBL1886967 | 0.76 | CYP19A1 (0.54) | CYP19A1TSHRLMNAHTTMEN1 | |
| SCHEMBL1316710 | 0.76 | TSHR (0.64) | CYP19A1TSHRLMNAHTTMEN1 | |
| SCHEMBL5495288 | 0.76 | HTT (0.57) | CYP19A1TSHRLMNAHTTMEN1 | |
| SCHEMBL716259 | 0.76 | CYP19A1 (0.54) | CYP19A1TSHRLMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378120-B2 | Method and reagent for measuring nitroreductase enzyme activity | GE HEALTHCARE UK LIMITED (GB) | 2013-02-19 | — | — | US | disclosed |
| US-20090325209-A1 | METHOD AND REAGENT FOR MEASURING NITROREDUCTASE ENZYME ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2009-12-31 | — | — | US | disclosed |
| US-7579140-B2 | Method and reagent for measuring nitroreductase enzyme activity | GE HEALTHCARE UK LIMITED (GB) | 2009-08-25 | — | — | US | disclosed |
| US-20080317674-A1 | Method and Reagent for Measuring Nitroreductase Enzyme Activity | GE HEALTHCARE UK LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| EP-1749103-A1 | METHOD AND REAGENT FOR MEASURING NITROREDUCTASE ENZYME ACTIVITY | GE Healthcare UK Limited (GB) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005118839-A1 | METHOD AND REAGENT FOR MEASURING NITROREDUCTASE ENZYME ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2005-12-15 | — | — | WO | disclosed |
| US-6828116-B1 | Energy transfer assay method and reagent | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2004-12-07 | — | — | US | disclosed |
| EP-1086179-B1 | ENERGY TRANSFER ASSAY METHOD AND REAGENT | AMERSHAM BIOSCIENCES UK LTD (GB) | 2003-04-23 | — | — | EP | disclosed |
| EP-1086179-A1 | ENERGY TRANSFER ASSAY METHOD AND REAGENT | Amersham Pharmacia Biotech UK Ltd. (GB) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064519-A1 | ENERGY TRANSFER ASSAY METHOD AND REAGENT | AMERSHAM BIOSCIENCES CORP (GB) | 1999-12-16 | — | — | WO | disclosed |
| EP-0452725-B1 | Fluorine containing diaminobenzene derivatives and its use | SAGAMI CHEM RES (JP) | 1995-11-08 | — | — | EP | disclosed |
| EP-0635533-A1 | Polyimide-based liquid crystal aligning agent | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5153304-A | Polyimides; liquid crystal tilting agent; water-repelling | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-10-06 | — | — | US | disclosed |
| US-5144078-A | Polyimide intermediates | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-09-01 | — | — | US | disclosed |
| EP-0452725-A2 | Fluorine containing diaminobenzene derivatives and its use | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325209-A1 | METHOD AND REAGENT FOR MEASURING NITROREDUCTASE ENZYME ACTIVITY | CBR3, CBR1, ADH7 | CYP19A1 904/4885TSHR 1313/4885LMNA 3842/4885 |
| US-20080317674-A1 | Method and Reagent for Measuring Nitroreductase Enzyme Activity | CBR3, CBR1, SQOR | CYP19A1 1013/4885TSHR 1499/4885LMNA 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.