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Sugi Predict / Targets / ADH7

ADH7

All-trans-retinol dehydrogenase [NAD(+)] ADH7 · P40394 · ADH7 on Sugi Atlas →

16,916 patent compounds predicted against ADH7, 9,791 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL76963 SCHEMBL76963 1.00 4/20
SCHEMBL79600 SCHEMBL79600 1.00 4/20
SCHEMBL145544 SCHEMBL145544 1.00 4/20
Heptylformamide Heptylformamide (SCHEMBL146004) 1.00 4/20
SCHEMBL148472 SCHEMBL148472 1.00 4/20
SCHEMBL149028 SCHEMBL149028 1.00 4/20
SCHEMBL163669 SCHEMBL163669 1.00 4/20
SCHEMBL302735 SCHEMBL302735 1.00 4/20
SCHEMBL302790 SCHEMBL302790 1.00 4/20
SCHEMBL303563 SCHEMBL303563 1.00 4/20
SCHEMBL303653 SCHEMBL303653 1.00 4/20
SCHEMBL305123 SCHEMBL305123 1.00 4/20
SCHEMBL302803 SCHEMBL302803 0.61 4/20
SCHEMBL278039 SCHEMBL278039 0.41 4/20
SCHEMBL277123 SCHEMBL277123 1.00 3/20
SCHEMBL277517 SCHEMBL277517 1.00 3/20
SCHEMBL303776 SCHEMBL303776 1.00 3/20
SCHEMBL277250 SCHEMBL277250 0.96 3/20
SCHEMBL245391 SCHEMBL245391 0.94 3/20
SCHEMBL645299 SCHEMBL645299 0.94 3/20

Clinical trials — most relevant to ADH7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
cindilizumab + Bevacizumab + Coenzyme I for Injection in Unresectable Hepatocellular Carcinoma PHASE4UNKNOWN
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis PHASE4NOT_YET_RECRUITING
High Dose Vitamin B1 to Reduce Abusive Alcohol Use PHASE4COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
IST Neoadjuvant Abraxane in Newly Diagnosed Breast Cancer PHASE2UNKNOWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
Folate Rechallenge PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Sirtuin-NAD Activator in Alzheimer's Disease PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Vitamin D Intervention Trial in Healthy Chinese, Phase II PHASE1COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
ALDH2 Genetic Testing in East Asian Community nanNOT_YET_RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis nanCOMPLETED
Nutritional Assessment in Patient of Mucopolysaccharide nanNOT_YET_RECRUITING
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients nanRECRUITING
Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism nanRECRUITING
Development of an Optimal Micronutrient Reference Range for Adults nanCOMPLETED
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China nanCOMPLETED
Mucomyst for Hepatitis C nanSUSPENDED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Metabolic Availability of Lysine From Barley in Young Adult Men nanNOT_YET_RECRUITING
Environmental & Genetic Influences on Vitamin D Status nanCOMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Adrenoleukodystrophy National Registry Study nanRECRUITING
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM nanCOMPLETED
Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death nanCOMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ADH7 binder may also engage these)

ProteinNameSimilarity
Q64415 — 1.000 Q64415 →
O97959 — 0.997 O97959 →
Q64437 — 0.997 Q64437 →
P22797 — 0.997 P22797 →
P00328 — 0.997 P00328 →
Q9Z2M2 — 0.997 Q9Z2M2 →
ADH1C Alcohol dehydrogenase 1C 0.996 landscape →
P86885 — 0.996 P86885 →
P86883 — 0.995 P86883 →
P80222 — 0.994 P80222 →
P41680 — 0.994 P41680 →
P00329 — 0.994 P00329 →
Q64413 — 0.994 Q64413 →
P19631 — 0.994 P19631 →
P80338 — 0.994 P80338 →
P28469 — 0.994 P28469 →
P49645 — 0.993 P49645 →
P25406 — 0.993 P25406 →
P23991 — 0.993 P23991 →
ADH4 All-trans-retinol dehydrogenase [NAD(+)] ADH4 0.993 landscape →
A1L4Y2 — 0.993 A1L4Y2 →
P41681 — 0.993 P41681 →
P00327 — 0.993 P00327 →
P41682 — 0.992 P41682 →
P14139 — 0.992 P14139 →
P93629 — 0.992 P93629 →
Q03505 — 0.992 Q03505 →
P26325 — 0.992 P26325 →
ADH1A Alcohol dehydrogenase 1A 0.992 landscape →
Q64563 — 0.992 Q64563 →