Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 14/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456756 | 0.88 | CYP2C9 (0.53) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL30277283 | 0.82 | CYP2C9 (0.48) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL19962270 | 0.82 | CYP2C9 (0.48) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL14313728 | 0.81 | GPR139 (0.51) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL20581332 | 0.79 | CYP2C9 (0.46) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL15450829 | 0.79 | TRPV4 (0.46) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL18066928 | 0.79 | TRPV4 (0.46) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL30050122 | 0.79 | GPR139 (0.52) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL27160044 | 0.79 | GPR139 (0.52) | GPR139CYP2C9NR1I2MAPK1P2RX3 | |
| SCHEMBL27160041 | 0.79 | GPR139 (0.52) | GPR139CYP2C9NR1I2MAPK1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094684-A2 | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN 2-ONES AS CB1 RECEPTOR MODULATORS | Eli Lilly & Company (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070306-A2 | 1,5-DIPHENYL-3-BENZYLAMIN0-1,5-DIHYDR0PYRR0LIDIN-2-0NE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-06-12 | — | — | WO | disclosed |