Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20627632 | 0.90 | FGFR1 (0.60) | FGFR1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14748166 | 0.84 | FGFR1 (0.61) | FGFR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19848656 | 0.83 | FGFR1 (0.76) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL3846616 | 0.82 | HCAR1 (0.49) | FGFR1ALDH1A1HCAR1HTTHPGD | |
| SCHEMBL19848657 | 0.82 | FGFR1 (0.55) | FGFR1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL19350794 | 0.81 | FGFR1 (0.62) | FGFR1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29623644 | 0.81 | FGFR1 (0.62) | FGFR1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15638670 | 0.81 | HCAR1 (0.48) | FGFR1ALDH1A1HCAR1HTTHPGD | |
| SCHEMBL31144757 | 0.81 | HCAR1 (0.48) | FGFR1ALDH1A1HCAR1HTTHPGD | |
| SCHEMBL31144722 | 0.77 | FGFR1 (0.51) | FGFR1MAPTALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |