Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350794 | 1.00 | FGFR1 (0.62) | FGFR1MAPTALDH1A1SMN1; SMN2THRB | |
| SCHEMBL13836852 | 0.86 | FGFR1 (0.81) | FGFR1MAPTALDH1A1SMN1; SMN2MKNK1 | |
| SCHEMBL2642025 | 0.84 | FGFR1 (0.46) | FGFR1MAPTALDH1A1SMN1; SMN2THRB | |
| SCHEMBL11679463 | 0.83 | FGFR1 (0.66) | FGFR1ALDH1A1HTT | |
| SCHEMBL19848504 | 0.82 | ALDH1A1 (0.49) | FGFR1MAPTALDH1A1SMN1; SMN2THRB | |
| SCHEMBL29623727 | 0.81 | FGFR1 (0.59) | FGFR1MAPTALDH1A1SMN1; SMN2MKNK1 | |
| SCHEMBL19350767 | 0.81 | FGFR1 (0.59) | FGFR1MAPTALDH1A1SMN1; SMN2MKNK1 | |
| SCHEMBL20603947 | 0.81 | FGFR1 (0.67) | FGFR1SMN1; SMN2THRB | |
| SCHEMBL3852532 | 0.81 | FGFR1 (0.54) | FGFR1MAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL19350708 | 0.81 | FGFR1 (0.71) | FGFR1MAPTALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | claimed |
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |