Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.58 |
| ▸ | SORD | Q00796 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847734 | 0.79 | NCF1 (0.70) | NCF1ALDH1A1SLC22A12NPSR1HTT | |
| SCHEMBL3846343 | 0.79 | NCF1 (0.58) | NCF1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22715673 | 0.78 | NCF1 (0.76) | NCF1ALDH1A1SLC22A12NPSR1HTT | |
| SCHEMBL29472100 | 0.78 | NCF1 (0.76) | NCF1ALDH1A1SLC22A12NPSR1HTT | |
| SCHEMBL3850039 | 0.77 | SORD (0.40) | NCF1SORDALDH1A1MCOLN3NPSR1 | |
| SCHEMBL731691 | 0.76 | NCF1 (0.74) | NCF1ALDH1A1SLC22A12NPSR1HTT | |
| SCHEMBL1777402 | 0.75 | NCF1 (0.64) | NCF1ALDH1A1SLC22A12SMN1; SMN2MEN1 | |
| SCHEMBL30734145 | 0.75 | NCF1 (0.67) | NCF1ALDH1A1NPSR1KDM4EHTT | |
| SCHEMBL3848428 | 0.74 | NCF1 (0.56) | NCF1ALDH1A1SLC22A12 | |
| SCHEMBL3847838 | 0.74 | SORD (0.38) | NCF1SORDALDH1A1MCOLN3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |