Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | NRAS | P01111 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 4/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848404 | 0.82 | DYRK1A (0.38) | FLT3 | |
| SCHEMBL5851881 | 0.80 | TGFBR1 (0.37) | FLT3NRASCLK1IRAK4 | |
| SCHEMBL5852367 | 0.79 | PDE10A (0.34) | FLT3NRASCLK1IRAK4 | |
| SCHEMBL3846530 | 0.78 | TGFBR1 (0.40) | FLT3NRASCLK1IRAK4 | |
| SCHEMBL3852711 | 0.78 | CLK1 (0.36) | FLT3NRASCLK1IRAK4 | |
| SCHEMBL3847098 | 0.76 | AKT1 (0.33) | — | |
| SCHEMBL3328639 | 0.74 | CLK1 (0.36) | FLT3NRASCLK1IRAK4 | |
| SCHEMBL3844955 | 0.74 | MET (0.32) | — | |
| SCHEMBL3852870 | 0.72 | TGFBR1 (0.32) | — | |
| SCHEMBL3850259 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |