Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nabumetone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nabumetone SCHEMBL29373228 | 1.00 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL29570823 | 1.00 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL2256 | 1.00 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL28775077 | 0.98 | CYP1A2 (0.97) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL104942 | 0.98 | CYP1A2 (0.97) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL23064140 | 0.97 | CYP1A2 (0.94) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL7554060 | 0.95 | CYP1A2 (0.91) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL3362072 | 0.93 | RAB9A (0.86) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL2325715 | 0.91 | CYP1A2 (0.83) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| SCHEMBL17288829 | 0.90 | CYP1A2 (0.82) | CYP1A2KDM4ELMNAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012166973-A1 | METHODS FOR PROMOTING CELL REPROGRAMMING | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-12-06 | — | — | WO | disclosed |
| WO-2012151309-A1 | METHODS FOR REGULATING INDUCED PLURIPOTENT STEM CELL GENERATION AND COMPOSITIONS THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-11-08 | — | — | WO | disclosed |
| EP-2054052-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | Vicus Therapeutics SPE 1, LLC (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008014471-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | VICUS THERAPEUTICS SPE 1, LLC (US) | 2008-01-31 | — | — | WO | disclosed |
| WO-2006083508-A2 | COMBINATIONS OF SUPEROXIDE DISMUTASE MIMETICS AND NONSTEROIDAL ANALGESIC/ANTI-INFLAMMATORY DRUGS | METAPHORE PHARMACEUTICALS INC. (US) | 2006-08-10 | — | — | WO | disclosed |
| EP-1551370-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1549742-A1 | METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF | Tjötta, Enok (NO) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004055175-A1 | METHOD FOR SELECTION OF COMPOUNDS WHICH INHIBIT CLONAL CELL GROWTH AND USE THEREOF | TJOETTA ENOK (NO) | 2004-07-01 | — | — | WO | disclosed |
| WO-2004032900-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2004-04-22 | — | — | WO | disclosed |
| US-20040028582-A1 | Crystallization process for producing fine crystal products | SMITHKLINE BEECHAM CORPORATION | 2004-02-12 | — | — | US | disclosed |