Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.35 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27419739 | 0.92 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL27804540 | 0.85 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL27847728 | 0.82 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL11302173 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL8580139 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Pentaethylene Glycol SCHEMBL10931229 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL426935 | 0.79 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2636987 | 0.79 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL9297235 | 0.78 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| SCHEMBL3709992 | 0.78 | TSHR (0.48) | ALDH1A1TSHRCYP2D6CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | claimed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | claimed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | claimed |
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | disclosed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | disclosed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | disclosed |
| US-9687387-B2 | System and methods for treating ear disorders | YAACOBI YOSEPH (US) | 2017-06-27 | — | — | US | disclosed |
| US-9428714-B2 | Method of increasing the performance of cationic fabric softeners | THE DIAL CORPORATION (US) | 2016-08-30 | — | — | US | disclosed |
| US-20160022666-A1 | Systems and Methods for Treating Ear Disorders and Formulations Therefor | YAACOBI YOSEPH (US) | 2016-01-28 | — | — | US | disclosed |
| EP-2968999-A1 | SYSTEMS AND METHODS FOR TREATING EAR DISORDERS AND FORMULATIONS THEREFOR | Yaacobi, Yoseph (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20140348959-A1 | Formulations and Methods for Treating Ear Conditions | PARTICLE SCIENCES, INC. | 2014-11-27 | — | — | US | disclosed |
| US-4267067-A | Process for augmenting or enhancing the aroma of a detergent using 2-oxabicyclooctane derivative | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4263149-A | FOR PERFUMING FABRIC SOFTENERS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1981-04-21 | — | — | US | disclosed |
| US-4263208-A | FROM DIENE, ALDEHYDE, GRIGNARD REAGENT | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1981-04-21 | — | — | US | disclosed |
| US-4248250-A | Use of cyclic chemical compounds for augmenting or enhancing the aroma or taste of smoking tobacco and smoking tobacco article | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1981-02-03 | — | — | US | disclosed |
| US-4247423-A | CHEMICAL INTERMEDIATES OF 2-OXABICYCLO(2.2.2)OCTANE DERIVATIVES; FOODS; TOBACCO | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4238344-A | ALCOHOL AND ESTER DERIVATIVES OF CYCLOHEXENE; 2-OXABICYCLO(2.2.2)OCTANES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4231940-A | 2-Oxabicyclooctane derivatives | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1980-11-04 | — | — | US | disclosed |
| US-4207214-A | 2-Oxabicyclooctane derivatives in perfume compositions | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4195099-A | Use of 2-oxabicyclooctane derivatives, for augmenting or enhancing the flavor of foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1980-03-25 | — | — | US | disclosed |