Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652078 | 0.89 | MAPT (0.46) | MAPTLMNAGAAKDM4EF10 | |
| SCHEMBL14599486 | 0.86 | GAA (0.53) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL22397770 | 0.83 | POLB (0.52) | MAPTLMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL13327274 | 0.83 | POLB (0.52) | MAPTLMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL13239764 | 0.83 | MAPT (0.47) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL7138685 | 0.82 | MAPT (0.65) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3219970 | 0.79 | FABP5 (0.49) | MAPTLMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL4118503 | 0.79 | MAPT (0.71) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL8222797 | 0.78 | TSHR (0.50) | LMNAGAAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL30555288 | 0.78 | TSHR (0.50) | LMNAGAAALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357506-B2 | Method of identifying improved conjugates of biologically active compounds | BURNET MICHAEL (DE) | 2013-01-22 | — | — | US | disclosed |
| US-7579324-B2 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | C-A-I-R BIOSCIENCES GMBH (DE) | 2009-08-25 | — | — | US | disclosed |
| US-20090093014-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | Burnet, Dr. Michael (DE) | 2009-04-09 | — | — | US | disclosed |
| US-20080145343-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | BURNET, MICHAEL (DE) | 2008-06-19 | — | — | US | disclosed |
| EP-1483277-A4 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF | MERCKLE GMBH (DE) | 2007-10-03 | — | — | EP | disclosed |
| EP-1483579-A4 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF | MERCKLE GMBH (DE) | 2006-07-12 | — | — | EP | disclosed |
| US-20060099660-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | SYNOVO GMBH (DE) | 2006-05-11 | — | — | US | disclosed |
| US-20050171342-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | MERCKLE GMBH (DE) | 2005-08-04 | — | — | US | disclosed |
| EP-1483579-A2 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF | Sympore GmbH (DE) | 2004-12-08 | — | — | EP | disclosed |
| EP-1483277-A2 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF | Sympore GmbH (DE) | 2004-12-08 | — | — | EP | disclosed |
| US-20040087517-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | C-A-I-R BIOSCIENCES GMBH (DE) | 2004-05-06 | — | — | US | disclosed |
| US-20040005641-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | BURNET, DR. MICHAEL (DE) | 2004-01-08 | — | — | US | disclosed |
| WO-2003070173-A2 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF | SYMPORE GMBH (DE) | 2003-08-28 | — | — | WO | disclosed |
| WO-2003070174-A2 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF | SYMPORE GMBH (DE) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080145343-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | CD47, CD14, CD4 | MAPT 3182/4885LMNA 2485/4885GAA 304/4885 |
| US-20050171342-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | SLC7A1, CD4, SLC11A2 | MAPT 2888/4885LMNA 2042/4885GAA 551/4885 |
| US-20040005641-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | CD47, CD14, CD4 | MAPT 3182/4885LMNA 2485/4885GAA 304/4885 |
| US-20040087517-A1 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof | SLC7A1, SLC47A1, SLC47A2 | MAPT 2676/4885LMNA 1557/4885GAA 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.