Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | NRAS | P01111 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5853292 | 0.99 | FLT3 (0.42) | FLT3NRASDDR1EPHB3LCK | |
| SCHEMBL3846110 | 0.87 | FLT3 (0.44) | FLT3NRASPTK6AURKBMAPK1 | |
| Hydrochloric Acid SCHEMBL5854241 | 0.86 | FLT3 (0.43) | FLT3NRASPTK6AURKBMAPK1 | |
| Hydrochloric Acid SCHEMBL3846279 | 0.85 | MET (0.42) | FLT3NRASEPHB3PTK6AURKB | |
| SCHEMBL4712318 | 0.84 | KDM4E (0.41) | FLT3NRASMAPK1KDM4ECHEK1 | |
| Hydrochloric Acid SCHEMBL3852303 | 0.84 | TRPV1 (0.48) | FLT3NRASDDR1LCKPTK6 | |
| Hydrochloric Acid SCHEMBL3849122 | 0.84 | KDM4E (0.40) | FLT3NRASPTK6MAPK1KDM4E | |
| Hydrochloric Acid SCHEMBL3846953 | 0.82 | KIT (0.39) | FLT3NRASPTK6KDM4EHPGD | |
| SCHEMBL3845909 | 0.82 | EPHB3 (0.41) | DDR1EPHB3TRPV1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3845647 | 0.82 | LRRK2 (0.45) | FLT3NRASPTK6AURKBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |