Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848144 | 0.86 | TGFBR1 (0.50) | TGFBR1TGFBR2 | |
| SCHEMBL13874572 | 0.82 | TGFBR1 (0.42) | TGFBR1TGFBR2 | |
| SCHEMBL3851642 | 0.82 | TGFBR1 (0.45) | TGFBR1TGFBR2 | |
| SCHEMBL3847341 | 0.79 | TGFBR1 (0.48) | TGFBR1TGFBR2 | |
| SCHEMBL3846134 | 0.77 | TGFBR1 (0.46) | TGFBR1TGFBR2 | |
| SCHEMBL3847649 | 0.76 | KDM4E (0.39) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL3847367 | 0.75 | PIK3CA (0.42) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL3851330 | 0.74 | PIK3CA (0.39) | TGFBR1PIK3CAPIK3CB | |
| SCHEMBL3845273 | 0.74 | FLT3 (0.47) | TGFBR1PIK3CA | |
| SCHEMBL19806492 | 0.74 | TGFBR1 (0.62) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |