Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 17/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854358 | 0.89 | CHRM4 (0.41) | CHRM4 | |
| SCHEMBL3855265 | 0.86 | CHRM4 (0.36) | CHRM4PDE3BPDE3APDE10ARET | |
| SCHEMBL3847448 | 0.86 | CHRM4 (0.38) | CHRM4PDE3BPDE3APDE10A | |
| SCHEMBL3849596 | 0.85 | CHRM4 (0.44) | CHRM4 | |
| SCHEMBL3848852 | 0.83 | ALDH1A1 (0.43) | — | |
| SCHEMBL3846957 | 0.82 | NCF1 (0.48) | — | |
| SCHEMBL3850517 | 0.81 | CYP46A1 (0.42) | — | |
| SCHEMBL3850033 | 0.81 | NCF1 (0.36) | — | |
| SCHEMBL3846323 | 0.81 | NCF1 (0.33) | CHRM4 | |
| SCHEMBL14145430 | 0.81 | CHRM4 (0.46) | CHRM4PDE3BPDE3APDE10ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |