Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.30 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626233 | 0.87 | EGLN1 (0.34) | HTTEGLN1SPRP2RX7SMN1; SMN2 | |
| SCHEMBL1627688 | 0.87 | EGLN1 (0.44) | EGLN1P2RX7SMN1; SMN2HTR2ASLC6A5 | |
| SCHEMBL12720392 | 0.87 | EGLN1 (0.36) | HTTEGLN1ALDH1A1SPRP2RX7 | |
| SCHEMBL3865775 | 0.85 | HTT (0.41) | HTTEGLN1ALDH1A1KDM4ESPR | |
| SCHEMBL3864870 | 0.83 | SPR (0.39) | HTTEGLN1ALDH1A1KDM4ESPR | |
| SCHEMBL3859450 | 0.81 | EGLN1 (0.35) | HTTEGLN1ALDH1A1P2RX7SMN1; SMN2 | |
| SCHEMBL1625317 | 0.78 | SPR (0.47) | HTTALDH1A1KDM4EHSD17B10SPR | |
| SCHEMBL3861436 | 0.74 | SPR (0.48) | HTTEGLN1ALDH1A1KDM4ESPR | |
| SCHEMBL1627956 | 0.73 | SPR (0.50) | EGLN1ALDH1A1KDM4EHSD17B10SPR | |
| SCHEMBL3856424 | 0.72 | SPR (0.35) | EGLN1SPRSMN1; SMN2HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008076427-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |