Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628517 | 0.86 | PTPRC (0.41) | SPREGLN1HDAC1MAPK1 | |
| SCHEMBL3861436 | 0.86 | SPR (0.48) | SPREGLN1MEN1KMT2AMAPK1 | |
| SCHEMBL12720457 | 0.85 | EGLN1 (0.39) | SPREGLN1HPGDMAPK14 | |
| SCHEMBL1625405 | 0.85 | EGLN1 (0.47) | EGLN1HPGDSMN1; SMN2 | |
| SCHEMBL3865775 | 0.78 | HTT (0.41) | SPREGLN1MAPTMEN1KMT2A | |
| SCHEMBL3864870 | 0.74 | SPR (0.39) | SPREGLN1MEN1KMT2A | |
| SCHEMBL1627204 | 0.73 | SPR (0.46) | SPREGLN1HDAC1MAPTRAB9A | |
| SCHEMBL3840046 | 0.73 | SPR (0.39) | SPREGLN1MAPTKMT2AHPGD | |
| SCHEMBL3837300 | 0.73 | SPR (0.39) | SPREGLN1MEN1KMT2ATP53 | |
| SCHEMBL3855928 | 0.72 | HTT (0.34) | SPREGLN1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008076427-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |