Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 8/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 8/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 8/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853643 | 1.00 | PDK1 (0.40) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL3854657 | 0.91 | PDK1 (0.42) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL3854646 | 0.91 | PDK1 (0.42) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL3858814 | 0.89 | PDK1 (0.39) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL3856517 | 0.89 | PDK1 (0.39) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL3855286 | 0.88 | CPS1 (0.43) | KMT2AMGLLMEN1 | |
| SCHEMBL3861316 | 0.85 | KMT2A (0.49) | KMT2AMEN1 | |
| SCHEMBL3854629 | 0.85 | KMT2A (0.49) | KMT2AMEN1 | |
| SCHEMBL3860943 | 0.83 | KMT2A (0.46) | KMT2AMGLLMEN1 | |
| SCHEMBL3863242 | 0.83 | KMT2A (0.46) | KMT2AMGLLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585871-B2 | 4-{[(6R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 3-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 4-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; cytokine expression | WYETH (US) | 2009-09-08 | — | — | US | claimed |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | WYETH (US) | 2006-03-16 | — | — | US | claimed |
| US-7585871-B2 | 4-{[(6R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 3-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 4-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; cytokine expression | WYETH (US) | 2009-09-08 | — | — | US | disclosed |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | WYETH (US) | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058337-A1 | Phenanthridine carbonyl phenols | MT-CO2, PAH, CBR3 | PDK1 821/4885PDK2 695/4885PDK3 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.