Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 18/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Motapizone SCHEMBL385669 | 0.80 | PDE3B (0.65) | PDE3APDE4BPDE3BPDE4APDE4C | |
| Motapizone SCHEMBL10671058 | 0.79 | PDE3B (0.64) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10730608 | 0.69 | PDE3B (0.67) | PDE3APDE4BPDE3BPDE4APDE4C | |
| Motapizone SCHEMBL6560835 | 0.68 | PDE4A (0.52) | PDE3APDE4BPDE3BPDE4APDE4C | |
| Bemarinone SCHEMBL782956 | 0.68 | PDE3B (0.60) | PDE3APDE3B | |
| Bemarinone SCHEMBL10344842 | 0.67 | PDE3B (0.58) | PDE3APDE3B | |
| Bemarinone SCHEMBL10345086 | 0.66 | PDE3B (0.57) | PDE3APDE3B | |
| SCHEMBL10729410 | 0.65 | PBRM1 (0.48) | PDE3APDE4BPDE3BPDE4APDE4C | |
| Ci-930 SCHEMBL6052113 | 0.65 | PDE3B (1.00) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10383108 | 0.65 | PDE3B (0.64) | PDE3APDE4BPDE3BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297243-B1 | TREATING OSTEOPENIA THAT ACCOMPANIES THE MENOPAUSE | NOVO NORDISK A/S (DK) | 2001-10-02 | — | — | US | claimed |