Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL12 | P48061 | 8/20 | 0.70 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | BACE1 | P56817 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | STAT3 | P40763 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA3 | P07451 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3856916 | 1.00 | CXCL12 (0.70) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3863009 | 0.91 | ALOX5 (0.62) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3863003 | 0.91 | ALOX5 (0.62) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3857011 | 0.89 | CXCL12 (0.70) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3857006 | 0.89 | CXCL12 (0.70) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3859793 | 0.89 | CA12 (0.61) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3859790 | 0.89 | CA12 (0.61) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL8965757 | 0.86 | CYP2D6 (0.72) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL8965766 | 0.86 | CYP2D6 (0.72) | CXCL12GSK3BBACE1CYP2D6CYP1A2 | |
| SCHEMBL3862265 | 0.84 | APP (0.64) | CXCL12GSK3BBACE1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589123-B2 | Chemical compounds | PHYTOPHARM PLC (GB) | 2009-09-15 | — | — | US | claimed |
| CN-101511350-A | Dioxo-alkanes and dioxo-alkenes | PHYTOPHARM PLC (GB) | 2009-08-19 | — | — | CN | disclosed |