Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10591348 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL313049 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL3862762 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL6324757 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL1116755 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL3868201 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL7994751 | 1.00 | RAB9A (0.39) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL10591685 | 0.97 | RAB9A (0.35) | RAB9APTPN7HMGCRRECQLTDP1 | |
| SCHEMBL291632 | 0.97 | — | — | |
| SCHEMBL9211208 | 0.93 | RECQL (0.41) | RAB9APTPN7HMGCRRECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7591995-B2 | Cobalamin conjugates useful as imaging and therapeutic agents | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-09-22 | — | — | US | disclosed |
| US-20090060837-A1 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | COLLINS DOUGLAS A | 2009-03-05 | — | — | US | disclosed |
| US-7468432-B2 | Cobalamin conjugates useful as antitumor agents | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-12-23 | — | — | US | disclosed |
| WO-2008136850-A2 | COBALAMIN CONJUGATES USEFUL AS IMAGING AND THERAPEUTIC AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-11-13 | — | — | WO | disclosed |
| US-20070116644-A1 | COBALAMIN CONJUGATES USEFUL AS IMAGING AND THERAPEUTIC AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2007-05-24 | — | — | US | disclosed |
| US-6838073-B1 | Cobalamin conjugates useful as imaging and therapeutic agents | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2005-01-04 | — | — | US | disclosed |
| US-6806363-B1 | DRUGS FOR DIAGNOSIS/THERAPY; RADIONUCLIDE-BASED TUMOR IMAGING | MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH | 2004-10-19 | — | — | US | disclosed |
| US-20040162240-A1 | Cobalamin conjugates useful as antitumor agents | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-08-19 | — | — | US | disclosed |
| EP-1239887-A1 | COBALAMIN CONJUGATES USEFUL AS IMAGING AND THERAPEUTIC AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1171162-A2 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6284784-B1 | 2-HYDROXYMETHYL DERIVATIVES | GEORGETOWN UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| WO-2001028595-A1 | COBALAMIN CONJUGATES USEFUL AS IMAGING AND THERAPEUTIC AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-04-26 | — | — | WO | disclosed |
| WO-2000062808-A2 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2000-10-26 | — | — | WO | disclosed |
| EP-1015427-A1 | SUBSTITUTED 2-PYRROLIDINONE ACTIVATORS OF PKC | GEORGETOWN UNIVERSITY (US) | 2000-07-05 | — | — | EP | disclosed |
| US-5962504-A | ACTIVATOR OF PROTEIN KINASE; ANTICANCER AGENT | GEORGETOWN UNIVERSITY (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1999012901-A1 | SUBSTITUTED 2-PYRROLIDINONE ACTIVATORS OF PKC | GEORGETOWN UNIVERSITY (US) | 1999-03-18 | — | — | WO | disclosed |
| EP-0421441-B1 | Pantothenic acid derivatives | FUJIREBIO KK (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5120738-A | Cardiovascular disorders | FUJIREBIO INC. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0421441-A2 | Pantothenic acid derivatives | FUJIREBIO INC. (JP) | 1991-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162240-A1 | Cobalamin conjugates useful as antitumor agents | MMAB, SLC19A2, SLC19A1 | RAB9A 1729/4885PTPN7 4190/4885HMGCR 760/4885 |
| US-20070116644-A1 | COBALAMIN CONJUGATES USEFUL AS IMAGING AND THERAPEUTIC AGENTS | MMAB, SLC19A1, SLC19A2 | RAB9A 1134/4885PTPN7 4654/4885HMGCR 673/4885 |
| US-20090060837-A1 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | MMAB, SLC19A2, SLC19A1 | RAB9A 1729/4885PTPN7 4190/4885HMGCR 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.