Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.73 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.73 |
| ▸ | BRAF | P15056 | 4/20 | 0.73 |
| ▸ | FLT3 | P36888 | 7/20 | 0.64 |
| ▸ | CSF1R | P07333 | 3/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831817 | 0.87 | KDR (0.77) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL2848934 | 0.84 | KDR (1.00) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL25405811 | 0.79 | KDR (0.81) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL2846085 | 0.79 | KDR (0.64) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL17229950 | 0.78 | FLT3 (1.00) | KDRFLT3RAF1PDGFRBKIT | |
| SCHEMBL29261085 | 0.77 | TRPA1 (0.66) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL26272089 | 0.76 | KDR (0.66) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL26274543 | 0.74 | TRPA1 (0.68) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL2842603 | 0.74 | KDR (0.78) | KDRMAPK14TNNI3KBRAFFLT3 | |
| SCHEMBL4548925 | 0.72 | KDR (0.82) | KDRMAPK14TNNI3KBRAFFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940844-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-30 | — | — | EP | claimed |