Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.64 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 5/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.51 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25405811 | 0.81 | KDR (0.81) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL29261085 | 0.81 | TRPA1 (0.66) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL3831817 | 0.81 | KDR (0.77) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL4548938 | 0.80 | KDR (0.76) | KDRBRAFMAPK14TNNI3KAURKB | |
| SCHEMBL2848934 | 0.79 | KDR (1.00) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL3857809 | 0.79 | KDR (0.73) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL25405894 | 0.78 | KDR (0.58) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL26272089 | 0.77 | KDR (0.66) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL4548914 | 0.76 | KDR (0.83) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL26274543 | 0.76 | TRPA1 (0.68) | KDRBRAFMAPK14TNNI3KFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592433-B2 | Compounds and compositions as protein kinase inhibitors | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2013-11-26 | — | — | US | claimed |
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-23 | — | — | US | claimed |
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | claimed |
| WO-2010056907-A2 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-20 | — | — | WO | claimed |
| EP-1940844-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-30 | — | — | EP | claimed |
| EP-1940844-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-07-09 | — | — | EP | claimed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | claimed |
| US-8592433-B2 | Compounds and compositions as protein kinase inhibitors | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2013-11-26 | — | — | US | disclosed |
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-23 | — | — | US | disclosed |
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-23 | — | — | US | disclosed |
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-12-23 | — | — | US | disclosed |
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2010056907-A2 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010036917-A1 | PREVENTION AND TREATMENT OF CANCER WITH RAS GENE MUTATION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-01 | — | — | WO | disclosed |
| EP-1940844-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-30 | — | — | EP | disclosed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324062-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | SYK, SRC, FYN | KDR 209/4885BRAF 78/4885MAPK14 303/4885 |
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | IAPP, PNLIP, GPR119 | KDR 4824/4885BRAF 2010/4885MAPK14 1692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.