Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 11/20 | 0.53 |
| ▸ | PNP | P00491 | 9/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857910 | 0.89 | HPRT1 (0.53) | HPRT1PNP | |
| SCHEMBL3857906 | 0.83 | HPRT1 (0.66) | HPRT1PNPPOLB | |
| SCHEMBL6266779 | 0.82 | TK1 (0.58) | HPRT1PNP | |
| SCHEMBL3856920 | 0.82 | CCNE1 (0.48) | POLB | |
| SCHEMBL3850993 | 0.81 | HSP90AB1 (0.43) | — | |
| SCHEMBL7627167 | 0.80 | PNP (0.58) | HPRT1PNPPOLB | |
| SCHEMBL3855227 | 0.80 | HPRT1 (0.54) | HPRT1PNP | |
| SCHEMBL17194164 | 0.79 | HPRT1 (0.52) | HPRT1PNPPOLB | |
| SCHEMBL15078165 | 0.79 | POLB (0.73) | HPRT1PNPPOLB | |
| SCHEMBL6834577 | 0.78 | PNP (0.56) | HPRT1PNPPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579332-B2 | Nucleobase phosphonate analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20050059637-A1 | Nucleobase phosphonate analogs for antiviral treatment | GILEAD SCIENCES, INC. | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059637-A1 | Nucleobase phosphonate analogs for antiviral treatment | TYMP, TK1, NUDT1 | HPRT1 16/4885PNP 15/4885POLB 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.