Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KDM5A | P29375 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.57 |
| ▸ | KDM6B | O15054 | 2/20 | 0.57 |
| ▸ | KDM4A | O75164 | 2/20 | 0.57 |
| ▸ | KDM5C | P41229 | 2/20 | 0.57 |
| ▸ | TET3 | O43151 | 1/20 | 0.57 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.57 |
| ▸ | ASPH | Q12797 | 1/20 | 0.57 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.57 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.57 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.57 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.57 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.57 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156043 | 0.92 | ALDH1A1 (0.49) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL16569986 | 0.91 | ALDH1A1 (0.53) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL3854386 | 0.88 | KDM5B (0.57) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL3807628 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL3853630 | 0.80 | HPGD (0.48) | ALDH1A1KDM5BKDM5AMAPTKDM5C | |
| SCHEMBL5808527 | 0.78 | ALDH1A1 (0.69) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL11619832 | 0.75 | HPGD (0.44) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL9540613 | 0.75 | MLYCD (0.57) | ALDH1A1KDM4EHPGDMLYCDTP53 | |
| SCHEMBL5808530 | 0.75 | ALDH1A1 (0.65) | ALDH1A1KDM5BKDM4EKDM5AMAPT | |
| SCHEMBL18864231 | 0.75 | MAPT (0.46) | ALDH1A1KDM5BKDM4EKDM5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618978-B2 | Amides as BACE inhibitors | ELI LILLY AND COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-7585885-B2 | Pyrrolidine derivatives useful as BACE inhibitors | ELI LILLY AND COMPANY (US) | 2009-09-08 | — | — | US | disclosed |
| US-20070225372-A1 | Amides as Bace Inhibitors | ELI LILLY AND COMPANY | 2007-09-27 | — | — | US | disclosed |
| US-20070213331-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BASE INHIBITORS | ELI LILLY AND COMPANY | 2007-09-13 | — | — | US | disclosed |
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225372-A1 | Amides as Bace Inhibitors | BACE2, BACE1, APP | ALDH1A1 661/4885KDM5B 332/4885KDM4E 453/4885 |
| US-20070213331-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BASE INHIBITORS | BACE1, BACE2, PSEN1 | ALDH1A1 1523/4885KDM5B 1044/4885KDM4E 1975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.