Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | F3 | P13726 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aziridine SCHEMBL3858499 | 1.00 | MAPT (0.57) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL37936 | 0.92 | MAPT (0.67) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL6031974 | 0.92 | MAPT (0.67) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL37935 | 0.92 | MAPT (0.67) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| Water SCHEMBL28081094 | 0.90 | MAPT (0.64) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| Fluoride SCHEMBL28142752 | 0.90 | MAPT (0.64) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL27826046 | 0.90 | MAPT (0.64) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| Chloroform SCHEMBL28195040 | 0.86 | MAPT (0.59) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| Acetone SCHEMBL29037563 | 0.86 | TDP1 (0.67) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| Chloroform SCHEMBL28195041 | 0.86 | MAPT (0.59) | MAPTLMNAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585986-B2 | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel | CHATHAM BIOTEC, LIMITED (CA) | 2009-09-08 | — | — | US | disclosed |
| US-20080033189-A1 | Semi-Synthesis Of Taxane Intermediates And Aziridine Analogues And Their Conversion To Paclitaxel And Docetaxel | CHATHAM BIOTEC, LIMITED (CA) | 2008-02-07 | — | — | US | disclosed |
| US-20070027331-A1 | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel | INNOVATIONAL HOLDINGS LLC | 2007-02-01 | — | — | US | disclosed |
| EP-1732911-A2 | SEMI-SYNTHESIS OF TAXANE INTERMEDIATES AND AZIRIDINE ANALOGUES AND THEIR CONVERSION TO PACLITAXEL AND DOCETAXEL | Chatham Biotec Ltd. (CA) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082875-A2 | SEMI-SYNTHESIS OF TAXANE INTERMEDIATES AND AZIRIDINE ANALOGUES AND THEIR CONVERSION TO PACLITAXEL AND DOCETAXEL | PHYTOGEN LIFE SCIENCES INC. (CA) | 2005-09-09 | — | — | WO | disclosed |
| US-20050192445-A1 | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel | PHYTOGEN LIFE SCIENCES INC. (CA) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027331-A1 | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel | CIAPIN1, CYP1B1, BRPF1 | MAPT 1077/4885LMNA 2367/4885HDAC3 2362/4885 |
| US-20050192445-A1 | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel | CIAPIN1, CYP1B1, BRPF1 | MAPT 1077/4885LMNA 2367/4885HDAC3 2362/4885 |
| US-20080033189-A1 | Semi-Synthesis Of Taxane Intermediates And Aziridine Analogues And Their Conversion To Paclitaxel And Docetaxel | CIAPIN1, CYP1B1, AZI2 | MAPT 1233/4885LMNA 2135/4885HDAC3 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.