Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3856121 | 0.87 | NFE2L2 (0.43) | NFE2L2TNFRSF1AMAPTBACE1APP | |
| SCHEMBL3857395 | 0.86 | NFE2L2 (0.45) | NFE2L2TNFRSF1AMAPTBACE1APP | |
| SCHEMBL12098191 | 0.82 | TNFRSF1A (0.40) | NFE2L2TNFRSF1AKMT2AALDH1A1THRB | |
| SCHEMBL12098212 | 0.77 | TNFRSF1A (0.34) | NFE2L2TNFRSF1AABCG2CYP1A1CYP1A2 | |
| SCHEMBL3855734 | 0.75 | NFE2L2 (0.33) | NFE2L2TNFRSF1ANPC1RAB9ALMNA | |
| SCHEMBL12098004 | 0.74 | TNFRSF1A (0.33) | NFE2L2TNFRSF1AABCG2 | |
| SCHEMBL3861970 | 0.74 | NFE2L2 (0.32) | NFE2L2TNFRSF1AABCG2 | |
| SCHEMBL1620557 | 0.71 | CA1 (0.39) | TNFRSF1AALDH1A1TDP1 | |
| SCHEMBL7713703 | 0.69 | LCK (0.44) | MAPTBACE1APPKMT2AMEN1 | |
| SCHEMBL3842254 | 0.67 | BACE1 (0.67) | NFE2L2MAPTBACE1APPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589123-B2 | Chemical compounds | PHYTOPHARM PLC (GB) | 2009-09-15 | — | — | US | disclosed |
| EP-2046311-A2 | DIOXO-ALKANES AND DIOXO-ALKENES | Phytopharm Plc (GB) | 2009-04-15 | — | — | EP | disclosed |
| US-20080045591-A1 | Chemical Compounds | VECTURA LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
| WO-2008003978-A2 | DIOXO-ALKANES AND DIOXO-ALKENES | PHYTOPHARM PLC (GB) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045591-A1 | Chemical Compounds | CYP11B1, CYP11B2, CYP2S1 | NFE2L2 234/4885TNFRSF1A 3063/4885MAPT 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.