Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indomethacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 9/20 | 0.98 |
| ▸ | PTGS1 known ✓ | P23219 | 4/20 | 0.98 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.98 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.98 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.98 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.98 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | PTGES | O14684 | 1/20 | 0.98 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.98 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indomethacin SCHEMBL3518614 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL29525957 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL9300 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL29353712 | 0.99 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23391006 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL8352438 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL1817813 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL6356562 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL22472310 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23632959 | 0.98 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688481-B1 | A COMPOSITION COMPRISING A PRO-INFLAMMATORY CYTOKINE INHIBITOR, EPIGALLOCATECHIN GALLATE AND A NON-STEROIDAL ANTI-INFLAMMATORY DRUG FOR TREATING A TENDON INJURY IN A PERFORMANCE ANIMAL BEING A HORSE. | TRACKSIDE TECH PTY LTD (AU) | 2021-06-16 | — | — | EP | claimed |
| US-20210145763-A1 | LOW THC HEMP EXTRACT AND METHOD OF TREATMENT OR PREVENTION OF AN EYE DISEASE | EYE CO PTY LTD. (AU) | 2021-05-20 | — | — | US | claimed |
| US-11000533-B2 | Connective tissue monitoring, compositions for connective tissue treatment and methods for treating connective tissue | TRACKSIDE TECHNOLOGIES PTY LTD. (AU) | 2021-05-11 | — | — | US | claimed |
| EP-3773651-A1 | LOW THC HEMP EXTRACT AND METHOD OF TREATMENT OR PREVENTION OF AN EYE DISEASE | Eye Co Pty Ltd. (AU) | 2021-02-17 | — | — | EP | claimed |
| WO-2019191800-A1 | LOW THC HEMP EXTRACT AND METHOD OF TREATMENT OR PREVENTION OF AN EYE DISEASE | EYE CO PTY LTD (AU) | 2019-10-10 | — | — | WO | claimed |
| US-20180125868-A1 | CONNECTIVE TISSUE MONITORING, COMPOSITIONS FOR CONNECTIVE TISSUE TREATMENT AND METHODS FOR TREATING CONNECTIVE TISSUE | TRACKSIDE TECHNOLOGIES PTY LTD. (AU) | 2018-05-10 | — | — | US | claimed |
| US-20140100201-A1 | CONNECTIVE TISSUE MONITORING, COMPOSITIONS FOR CONNECTIVE TISSUE TREATMENT AND METHODS FOR TREATING CONNECTIVE TISSUE | TRACKSIDE TECHNOLOGIES PTY LTD. (AU) | 2014-04-10 | — | — | US | claimed |
| EP-2688481-A1 | CONNECTIVE TISSUE MONITORING, COMPOSITIONS FOR CONNECTIVE TISSUE TREATMENT AND METHODS FOR TREATING CONNECTIVE TISSUE | Trackside Technologies Pty Ltd (AU) | 2014-01-29 | — | — | EP | claimed |
| WO-2012129589-A1 | CONNECTIVE TISSUE MONITORING, COMPOSITIONS FOR CONNECTIVE TISSUE TREATMENT AND METHODS FOR TREATING CONNECTIVE TISSUE | TRACKSIDE TECHNOLOGIES PTY LTD (AU) | 2012-10-04 | — | — | WO | claimed |
| EP-0473655-A4 | DIVALENT METAL SALTS OF INDOMETHACIN | — | 1992-05-20 | — | — | EP | claimed |
| EP-0473655-A1 | DIVALENT METAL SALTS OF INDOMETHACIN. | BIOCHEMICAL VETERINARY RES (AU) | 1992-03-11 | — | — | EP | claimed |
| WO-1990014337-A1 | DIVALENT METAL SALTS OF INDOMETHACIN | BIOCHEMICAL VETERINARY RESEARCH (AU) | 1990-11-29 | — | — | WO | claimed |
| EP-2688481-B1 | A COMPOSITION COMPRISING A PRO-INFLAMMATORY CYTOKINE INHIBITOR, EPIGALLOCATECHIN GALLATE AND A NON-STEROIDAL ANTI-INFLAMMATORY DRUG FOR TREATING A TENDON INJURY IN A PERFORMANCE ANIMAL BEING A HORSE. | TRACKSIDE TECH PTY LTD (AU) | 2021-06-16 | — | — | EP | disclosed |
| US-20210145763-A1 | LOW THC HEMP EXTRACT AND METHOD OF TREATMENT OR PREVENTION OF AN EYE DISEASE | EYE CO PTY LTD. (AU) | 2021-05-20 | — | — | US | disclosed |
| US-11000533-B2 | Connective tissue monitoring, compositions for connective tissue treatment and methods for treating connective tissue | TRACKSIDE TECHNOLOGIES PTY LTD. (AU) | 2021-05-11 | — | — | US | disclosed |
| US-20210069213-A1 | COMPOSITION AND METHOD OF TREATMENT FOR DRY A.M.D. (AGE RELATED MACULAR DEGENERATION) | EYE CO PTY LTD (AU) | 2021-03-11 | — | — | US | disclosed |
| US-5310936-A | Preparation of divalent metal salts of indomethacin | BIOCHEMICAL VETERINARY RESEARCH PTY. LTD. (AU) | 1994-05-10 | — | — | US | disclosed |
| EP-0473655-A4 | DIVALENT METAL SALTS OF INDOMETHACIN | — | 1992-05-20 | — | — | EP | disclosed |
| EP-0473655-A1 | DIVALENT METAL SALTS OF INDOMETHACIN. | BIOCHEMICAL VETERINARY RES (AU) | 1992-03-11 | — | — | EP | disclosed |
| WO-1990014337-A1 | DIVALENT METAL SALTS OF INDOMETHACIN | BIOCHEMICAL VETERINARY RESEARCH (AU) | 1990-11-29 | — | — | WO | disclosed |