Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473989 | 0.80 | GAA (0.50) | GAADDB1CRBNGSK3AGSK3B | |
| SCHEMBL14423336 | 0.75 | SIGMAR1 (0.55) | GAASIGMAR1KMT2AMEN1POLB | |
| SCHEMBL18768681 | 0.74 | SIGMAR1 (0.53) | GAAL3MBTL1SIGMAR1KMT2AMEN1 | |
| SCHEMBL1713728 | 0.74 | SIGMAR1 (0.63) | GAADDB1CRBNL3MBTL1SIGMAR1 | |
| SCHEMBL6272610 | 0.73 | SIGMAR1 (0.52) | GAAL3MBTL1SIGMAR1KMT2AMEN1 | |
| SCHEMBL29607448 | 0.72 | GAA (0.78) | GAADDB1CRBNL3MBTL1GSK3A | |
| SCHEMBL484888 | 0.71 | SIGMAR1 (0.59) | GAASIGMAR1KMT2AMEN1POLB | |
| SCHEMBL568477 | 0.71 | SIGMAR1 (0.53) | L3MBTL1SIGMAR1ALDH1A1SLC6A5 | |
| SCHEMBL4055438 | 0.71 | HRH3 (0.59) | L3MBTL1SIGMAR1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL1243957 | 0.70 | SIGMAR1 (0.52) | L3MBTL1SIGMAR1ALDH1A1SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624874-B1 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2009-11-04 | — | — | EP | disclosed |