Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135986 | 0.95 | ESR1 (0.58) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3976908 | 0.94 | ESR1 (0.55) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL7110390 | 0.91 | ALDH1A1 (0.51) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL7111266 | 0.90 | ESR1 (0.47) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3861641 | 0.89 | ESR1 (0.55) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL6136110 | 0.89 | ESR1 (0.44) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL11187364 | 0.88 | ESR1 (0.55) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3861662 | 0.88 | ESR1 (0.60) | ESR1ESR2MAPTSMN1; SMN2KDM4E | |
| SCHEMBL3886456 | 0.87 | ESR1 (0.54) | ESR1ESR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL7942835 | 0.87 | ALDH1A1 (0.46) | ESR1ESR2MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501441-B1 | Naphthyl compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501441-B1 | Naphthyl compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501441-B1 | Naphthyl compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 2009-03-10 | — | — | US | disclosed |
| US-6437137-B1 | REDUCING (NAPHTHALEN-1-YL)(4-(2-(1-PIPERDINYL)ETHOXY) PHENYL)METHANONE WITH A REDUCING AGENT IN THE PRESENCE OF A SOLVENT, HEATING TO REFLUX; FORMING (NAPHTHALEN-1-YL)(4-(2-(1-PIPERDINYL)ETHOXY)PHENYL)METHANE | ELI LILLY AND COMPANY | 2002-08-20 | — | — | US | disclosed |
| EP-0702961-B1 | Compositions for minimizing the uterotrophic effect of tamoxifen and its analogs | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6410564-B1 | Naphthyl compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY | 2002-06-25 | — | — | US | disclosed |
| EP-0703228-B1 | Naphthyl compounds, intermediates, processes, compositions involving them | LILLY CO ELI (US) | 2002-03-06 | — | — | EP | disclosed |
| US-5658931-A | ADMINISTERING A MIXTURE OF ANTIESTROGENS | ELI LILLY AND COMPANY (US) | 1997-08-19 | — | — | US | disclosed |
| US-5554628-A | A 1-(4-ALKOXYPHENYL-)NAPHTHALENE COMPOUND | ELI LILLY AND COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| WO-1996009052-A1 | A METHOD FOR INHIBITING MAMMALIAN BREAST CARCINOMA WITH TAMOXIFEN, AND ANALOGS THEREOF, AND CERTAIN NAPHTHYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |
| WO-1996009039-A1 | NAPHTHYL COMPOUNDS, INTERMEDIATES, PROCESSES, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |
| EP-0702961-A2 | Compositions for minimizing the uterotrophic effect of tamoxifen and its analogs | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0703228-A1 | Naphthyl compounds, intermediates, processes, compositions involving them | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5484796-A | Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |
| US-5484795-A | Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |
| US-5484797-A | Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |