Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862097 | 0.89 | ESR1 (0.52) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL6135986 | 0.85 | ESR1 (0.58) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3976908 | 0.83 | ESR1 (0.55) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL7110390 | 0.81 | ALDH1A1 (0.51) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL7111266 | 0.80 | ESR1 (0.47) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3886456 | 0.80 | ESR1 (0.54) | ESR1ESR2SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8609912 | 0.79 | ESR1 (0.51) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3861641 | 0.79 | ESR1 (0.55) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL11187364 | 0.78 | ESR1 (0.55) | ESR1ESR2MAPTSMN1; SMN2TP53 | |
| SCHEMBL3861662 | 0.78 | ESR1 (0.60) | ESR1ESR2MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895989-B1 | 1-[4-(Substituted alkoxy)benzyl] naphthalene compounds having estrogen inhibitory activity | LILLY CO ELI (US) | 2005-05-18 | — | — | EP | disclosed |
| US-6509356-B1 | Estrogen inhibitory activity method for the treatment of breast cancer in a woman comprising administering to a patient a therapeutically effective amount of a compound | ELI LILLY AND COMPANY | 2003-01-21 | — | — | US | disclosed |
| EP-0895989-A1 | 1-[4-(Substituted alkoxy)benzyl] naphthalene compounds having estrogen inhibitory activity | ELI LILLY AND COMPANY (US) | 1999-02-10 | — | — | EP | disclosed |