Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GPR3 | P46089 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2138542 | 0.73 | — | — | |
| Phenanthridine SCHEMBL28395978 | 0.72 | GPR3 (0.77) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL9106884 | 0.72 | GPR3 (1.00) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL30823553 | 0.72 | GPR3 (1.00) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL8666 | 0.72 | GPR3 (1.00) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL30914262 | 0.72 | GPR3 (1.00) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL11355234 | 0.71 | KDM4E (0.74) | KDM4EGPR3CYP3A4ERN1DUSP10 | |
| Phenanthridine SCHEMBL29087045 | 0.70 | GPR3 (0.87) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL23003530 | 0.70 | GPR3 (0.95) | KDM4EGPR3CYP3A4TOP2AADORA3 | |
| Phenanthridine SCHEMBL2422346 | 0.70 | GPR3 (0.95) | KDM4EGPR3CYP3A4TOP2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585871-B2 | 4-{[(6R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 3-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 4-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; cytokine expression | WYETH (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585871-B2 | 4-{[(6R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 3-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 4-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; cytokine expression | WYETH (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585871-B2 | 4-{[(6R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 3-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; 4-{[(6S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]carbonyl}phenol; cytokine expression | WYETH (US) | 2009-09-08 | — | — | US | disclosed |
| CN-101052623-A | Phenanthridine carbonyl phenols as cytokine modulators | WYETH CORP (US) | 2007-10-10 | — | — | CN | disclosed |
| CN-101052623-A | Phenanthridine carbonyl phenols as cytokine modulators | WYETH CORP (US) | 2007-10-10 | — | — | CN | disclosed |
| EP-1784391-A1 | PHENANTHRIDINE CARBONYL PHENOLS AS CYTOKINE EXPRESSION MODULATORS | Wyeth (US) | 2007-05-16 | — | — | EP | disclosed |
| EP-1784391-A1 | PHENANTHRIDINE CARBONYL PHENOLS AS CYTOKINE EXPRESSION MODULATORS | Wyeth (US) | 2007-05-16 | — | — | EP | disclosed |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | WYETH (US) | 2006-03-16 | — | — | US | disclosed |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | WYETH (US) | 2006-03-16 | — | — | US | disclosed |
| US-20060058337-A1 | Phenanthridine carbonyl phenols | WYETH (US) | 2006-03-16 | — | — | US | disclosed |
| WO-2006028875-A1 | PHENANTHRIDINE CARBONYL PHENOLS AS CYTOKINE MODULATORS | WYETH (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006028875-A1 | PHENANTHRIDINE CARBONYL PHENOLS AS CYTOKINE MODULATORS | WYETH (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058337-A1 | Phenanthridine carbonyl phenols | MT-CO2, PAH, CBR3 | KDM4E 864/4885GPR3 2995/4885CYP3A4 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.