Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | CA4 | P22748 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL124457 | 0.96 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL29524821 | 0.96 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL30712481 | 0.96 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL156757 | 0.96 | — | — | |
| Succinic Acid SCHEMBL6293065 | 0.92 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL107798 | 0.92 | — | — | |
| Succinic Acid SCHEMBL29586668 | 0.92 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL63118 | 0.92 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL2353390 | 0.92 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL2923816 | 0.92 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254195-A4 | DEICING COMPOSITIONS AND METHODS OF USE | DIVERSIFIED NATURAL PRODUCTS I (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1495087-A1 | WATER-ACTIVATED, EXOTHERMIC CHEMICAL DEICING FORMULATIONS | MICHIGAN STATE UNIVERSITY (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003089539-A1 | WATER-ACTIVATED, EXOTHERMIC CHEMICAL DEICING FORMULATIONS | MICHIGAN STATE UNIVERSITY (US) | 2003-10-30 | — | — | WO | disclosed |
| US-6623657-B1 | Succinic acid and/or succinic anhydride and neutralizing base; does not damage aircraft alloys or concrete runways | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-09-23 | — | — | US | disclosed |
| EP-1254195-A1 | DEICING COMPOSITIONS AND METHODS OF USE | Applied Carbo-Chemicals (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6287480-B1 | Deicing compositions and methods of use | APPLIED CARBOCHEMICALS, INC. | 2001-09-11 | — | — | US | disclosed |
| WO-2001051584-A1 | DEICING COMPOSITIONS AND METHODS OF USE | APPLIED CARBO-CHEMICALS (US) | 2001-07-19 | — | — | WO | disclosed |