Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loratadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 1.00 |
| ▸ | SLC6A15 | Q9H2J7 | 15/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CYP2C8 | P10632 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loratadine SCHEMBL4596 | 1.00 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL29380223 | 1.00 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL29441811 | 1.00 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL2166756 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529220 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL28800563 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529200 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529218 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL28594875 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL27891063 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110327441-A | A kind of Chinese medicine line spices directly acting on body surface and preparation method | 山东中医药大学第二附属医院 | 2019-10-15 | — | — | CN | disclosed |
| WO-2017139487-A1 | METHODS, AGENTS, AND DEVICES FOR LOCAL NEUROMODULATION OF AUTONOMIC NERVES | NORTHWIND MEDICAL, INC. (US) | 2017-08-17 | — | — | WO | disclosed |
| CN-104547496-A | Traditional Chinese medicine composition for moistening lung to arrest cough and preparation method thereof | QINGDAO MUNICIPAL HOSPITAL | 2015-04-29 | — | — | CN | disclosed |
| CN-104055886-A | Medicinal composition for treating chronic cough, and preparation method and application thereof | UNIV CHENGDU TRAD CN MEDICINE | 2014-09-24 | — | — | CN | disclosed |
| CN-101596197-B | Quick-release medicinal composition and preparation method thereof | UNIV PLA 3RD MILITARY MEDICAL | 2011-07-20 | — | — | CN | disclosed |
| CN-101596197-A | Quick-release medicinal composition and preparation method thereof | UNIV PLA 3RD MILITARY MEDICAL (CN) | 2009-12-09 | — | — | CN | disclosed |
| EP-1670427-A4 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX INC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1680121-A4 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX INC (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2007041584-A2 | IMPLANTABLE SENSORS, IMPLANTABLE PUMPS, AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041593-A2 | ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| EP-1680121-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | CombinatoRx, Incorporated (US) | 2006-07-19 | — | — | EP | disclosed |
| EP-1670427-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | CombinatoRx, Incorporated (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005037203-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED (US) | 2005-04-28 | — | — | WO | disclosed |
| WO-2005027839-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |
| EP-1507774-A1 | PROCESSES FOR PREPARATION OF POLYMORPHIC FORMS OF DESLORATADINE | BIOGAL GYOGYSZERGYAR RT. (HU) | 2005-02-23 | — | — | EP | disclosed |
| WO-2004108700-A1 | PROCESSES FOR PREPARATION OF POLYMORPHIC FORMS OF DESLORATADINE | TEVA GYOGYSZERGYAR RESZVENYTARSASAG (HU) | 2004-12-16 | — | — | WO | disclosed |
| EP-1140899-A1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY | SCHERING CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037457-A1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY | SCHERING CORPORATION (US) | 2000-06-29 | — | — | WO | disclosed |
| US-5639798-A | SLURRY REACTION OF SYNTHESIS GAS USING SELECTIVE CATALYST OF COBALT AND ZIRCONIUM ON ALUMINA YIELDS FIVE-CARBON(AND ABOVE) HYDROCARBONS | WEXFORD P.A. SYNCRUDE LIMITED PARTNERSHIP (US) | 1997-06-17 | — | — | US | disclosed |
| US-4042206-A | Monoblock hot tops with aligned fibrous material | AIKOH CO., LTD. (JA) | 1977-08-16 | — | — | US | disclosed |