Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loratadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 1.00 |
| ▸ | SLC6A15 | Q9H2J7 | 15/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CYP2C8 | P10632 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loratadine SCHEMBL29380223 | 1.00 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL29441811 | 1.00 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL3862958 | 1.00 | SLC6A15 (1.00) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL2166756 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529220 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL28800563 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529200 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL21529218 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL28594875 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F | |
| Loratadine SCHEMBL27891063 | 0.99 | SLC6A15 (0.98) | SLC6A15HRH1MEN1NPC1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 46995 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121265587-B | Use of oligomycin A for the preparation of a medicament for the competitive inhibition of EphB3 for reversing the resistance of Loratinib | AFFILIATED HOSPITAL OF NANTONG UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026104580-A1 | PHARMACEUTICAL COMPOSITIONS USING NON-ANIMAL ORIGIN MATRIX FORMERS AND METHODS OF MAKING THEREOF | CATALENT U.K. SWINDON ZYDIS LIMITED (GB) | 2026-05-21 | — | — | WO | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-20260131006-A1 | PHARMACEUTICAL COMPOSITIONS USING NON-ANIMAL ORIGIN MATRIX FORMERS AND METHODS OF MAKING THEREOF | CATALENT U.K. SWINDON ZYDIS LIMITED (GB) | 2026-05-14 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4734952-A1 | ORAL TABLET WITH IMPROVED UNIFORMITY OF CONTENT OF ACTIVES | Fertin Pharma A/S (DK) | 2026-05-06 | — | — | EP | claimed |
| US-20260115192-A1 | PHARMACEUTICAL COMPOSITIONS | SHENZHEN PHARMACIN CO LTD (CN) | 2026-04-30 | — | — | US | claimed |
| US-20260115161-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | LAMINAR PHARMACEUTICALS S A (ES) | 2026-04-30 | — | — | US | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| EP-0050336-A1 | Panel file used for storage of mainly rectangular relatively thin sheets, in particular microfiche | Thomsen, Preben West (DK) | 1982-04-28 | — | — | EP | claimed |
| EP-0046588-A1 | Method of and circuit arrangement for supplying current to a two-wire telecommunications line | International Standard Electric Corporation (US) | 1982-03-03 | — | — | EP | claimed |
| EP-0044885-A1 | Method and apparatus for determining at least one geometrical characteristic of the rail heads of a railway track | SPENO INTERNATIONAL S.A. (CH) | 1982-02-03 | — | — | EP | claimed |
| EP-0042544-A2 | Novel antihistamines, process for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-12-30 | — | — | EP | claimed |
| US-4282233-A | NO SEDATIVE EFFECT | SCHERING CORPORATION (US) | 1981-08-04 | — | — | US | claimed |
| EP-0010018-A1 | Method and apparatus for producing a small quadrangular flat bag and for filling this bag with a solid or liquid substance of a predetermined quantity | SOCIETE DES ETABLISSEMENTS THIMON (FR) | 1980-04-16 | — | — | EP | claimed |
| EP-0007343-A1 | METHOD AND APPARATUS FOR REGENERATING FILTERS | ENVIRONMENTAL INDUSTRIAL PRODUCTS, INC. (US) | 1980-02-06 | — | — | EP | claimed |
| WO-1979000655-A1 | BAND OF BAGS,PROCESS AND DEVICE FOR PRODUCING SUCH | SCHERZ W (DE) | 1979-09-06 | — | — | WO | claimed |
| EP-0003197-A1 | Grinding machine for very hard workpieces | SOCIETE EUROPEENNE DES PRODUITS REFRACTAIRES (FR) | 1979-07-25 | — | — | EP | claimed |
| WO-1979000086-A1 | METHOD AND APPARATUS FOR REGENERATING FILTERS | ENVIRONMENTAL IND PROD (US) | 1979-02-22 | — | — | WO | claimed |