Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | PTGES | O14684 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840726 | 1.00 | KCNH2 (0.45) | KCNH2FFAR1FFAR4PTGESDRD2 | |
| SCHEMBL3840832 | 0.98 | PTGES (0.46) | KCNH2FFAR1FFAR4PTGESDRD2 | |
| SCHEMBL3869938 | 0.92 | PTGES (0.47) | KCNH2FFAR1FFAR4PTGESDRD2 | |
| SCHEMBL235807 | 0.83 | PTGES (0.43) | KCNH2FFAR1FFAR4PTGESHAO1 | |
| SCHEMBL233926 | 0.83 | PTGES (0.43) | KCNH2FFAR1FFAR4PTGESHAO1 | |
| SCHEMBL233649 | 0.81 | PTGES (0.44) | KCNH2FFAR1FFAR4PTGESHAO1 | |
| SCHEMBL234655 | 0.75 | PTGES (0.46) | FFAR1FFAR4PTGESHAO1 | |
| SCHEMBL13959503 | 0.75 | PTGES (0.46) | FFAR1FFAR4PTGESDRD2DRD3 | |
| SCHEMBL15461604 | 0.74 | KCNH2 (0.40) | KCNH2FFAR1FFAR4PTGESHAO1 | |
| SCHEMBL235975 | 0.74 | PTGES (0.43) | KCNH2FFAR1FFAR4PTGESHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |