Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840726 | 0.98 | KCNH2 (0.45) | PTGESFFAR1FFAR4KCNH2DRD2 | |
| SCHEMBL3863069 | 0.98 | KCNH2 (0.45) | PTGESFFAR1FFAR4KCNH2DRD2 | |
| SCHEMBL3869938 | 0.94 | PTGES (0.47) | PTGESFFAR1FFAR4KCNH2DRD2 | |
| SCHEMBL233649 | 0.82 | PTGES (0.44) | PTGESFFAR1FFAR4KCNH2HAO1 | |
| SCHEMBL235807 | 0.81 | PTGES (0.43) | PTGESFFAR1FFAR4KCNH2HAO1 | |
| SCHEMBL233926 | 0.81 | PTGES (0.43) | PTGESFFAR1FFAR4KCNH2HAO1 | |
| SCHEMBL13959503 | 0.76 | PTGES (0.46) | PTGESFFAR1FFAR4DRD2DRD3 | |
| SCHEMBL234655 | 0.76 | PTGES (0.46) | PTGESFFAR1FFAR4HAO1 | |
| SCHEMBL3859067 | 0.75 | PTGES (0.51) | PTGESFFAR1FFAR4HAO1 | |
| SCHEMBL3836802 | 0.75 | PTGES (0.50) | PTGESFFAR1KCNH2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |