Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3868026 | 0.92 | HTR6 (0.85) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3857601 | 0.88 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3894916 | 0.86 | HTR6 (0.76) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3865029 | 0.84 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3857130 | 0.84 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3858528 | 0.84 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3858546 | 0.84 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3867524 | 0.84 | HTR6 (0.78) | HTR6DRD1 | |
| SCHEMBL3857169 | 0.83 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL3864640 | 0.83 | HTR6 (1.00) | HTR6DRD1HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592457-B2 | 3-aryl-3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-09-22 | — | — | US | claimed |
| EP-1650190-A1 | 3-aryl-3-methyl-quinoline-2,4-diones, preparation method thereof and pharmaceutical composition containing same | Korea Research Institute of Chemical Technology (KR) | 2006-04-26 | — | — | EP | claimed |
| US-20060084676-A1 | 3-aryl--3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-04-20 | — | — | US | claimed |
| US-7592457-B2 | 3-aryl-3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-09-22 | — | — | US | disclosed |
| US-7592457-B2 | 3-aryl-3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-09-22 | — | — | US | disclosed |
| US-7592457-B2 | 3-aryl-3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-09-22 | — | — | US | disclosed |
| EP-1954689-A4 | N-SUBSTITUTED-1H-QUINOLINE-2, 4-DIONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RES INST CHEM TECH (KR) | 2009-09-02 | — | — | EP | disclosed |
| US-20080275058-A1 | N-Substituted-1H-Quinoline-2,4-Diones, Preparation Method Thereof, And Pharmaceutical Composition Containing The Same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-11-06 | — | — | US | disclosed |
| EP-1954689-A1 | N-SUBSTITUTED-1H-QUINOLINE-2, 4-DIONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007032572-A1 | N-SUBSTITUTED-1H-QUINOLINE-2, 4-DIONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2007-03-22 | — | — | WO | disclosed |
| EP-1650190-A1 | 3-aryl-3-methyl-quinoline-2,4-diones, preparation method thereof and pharmaceutical composition containing same | Korea Research Institute of Chemical Technology (KR) | 2006-04-26 | — | — | EP | disclosed |
| US-20060084676-A1 | 3-aryl--3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084676-A1 | 3-aryl--3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same | HTR6, HTR3B, HTR2C | HTR6 1/4885DRD1 103/4885HTR1A 6/4885 |
| US-20080275058-A1 | N-Substituted-1H-Quinoline-2,4-Diones, Preparation Method Thereof, And Pharmaceutical Composition Containing The Same | HTR6, DRD2, HTR1D | HTR6 1/4885DRD1 10/4885HTR1A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.