Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.45 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3863593 | 0.91 | LMNA (0.55) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL13539252 | 0.85 | LMNA (0.53) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL73436 | 0.83 | F2RL3 (0.46) | LMNARAB9ASMN1; SMN2NPC1F2RL3 | |
| SCHEMBL774164 | 0.82 | TP53 (0.57) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL14875121 | 0.80 | F2RL3 (0.46) | LMNARAB9ASMN1; SMN2ALDH1A1POLB | |
| Bromide SCHEMBL3865729 | 0.80 | LMNA (0.49) | LMNARAB9ASMN1; SMN2NPC1F2RL3 | |
| SCHEMBL73916 | 0.80 | MBD2 (0.58) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL72902 | 0.79 | AKR1C3 (0.47) | LMNARAB9ASMN1; SMN2F2RL3MBD2 | |
| SCHEMBL74474 | 0.78 | F2RL3 (0.42) | LMNASMN1; SMN2ALDH1A1F2RL3MBD2 | |
| SCHEMBL3864619 | 0.78 | LMNA (0.50) | LMNARAB9ASMN1; SMN2NPC1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601846-B2 | Compounds having activity as inhibitors of apoptosis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-13 | — | — | US | disclosed |
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | BAD, CASP3, BAX | LMNA 1024/4885RAB9A 3287/4885SMN1; SMN2 3506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.