SCHEMBL3863707

SCHEMBL3863707

CCOC(=O)C1CN(Cc2ccncc2)CCN1C(=O)CC(c1ccccc1)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CACNA1A O00555 2/20 0.64
CACNA2D1 P54289 2/20 0.64
CACNB1 Q02641 2/20 0.64
HPGD P15428 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
AGTR2 P50052 1/20 0.47
KDM4E B2RXH2 3/20 0.46
TSHR P16473 2/20 0.46
CACNA1C Q13936 1/20 0.44
CCR2 P41597 1/20 0.44
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
GAA P10253 1/20 0.43
ALDH1A1 P00352 4/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3888401 0.83 CACNA2D1 (0.73) CACNA1ACACNA2D1CACNB1HPGDSMN1; SMN2
SCHEMBL3888407 0.80 CACNA2D1 (0.61) CACNA1ACACNA2D1CACNB1HPGDSMN1; SMN2
SCHEMBL10525548 0.79 L3MBTL1 (0.54) CACNA1ACACNA2D1CACNB1AGTR2KDM4E
SCHEMBL4182908 0.79 CACNA2D1 (1.00) CACNA1ACACNA2D1CACNB1HPGDSMN1; SMN2
SCHEMBL3862187 0.74 KDM4E (0.70) CACNA1ACACNA2D1CACNB1KDM4ETSHR
SCHEMBL124103 0.73 L3MBTL1 (0.55) SMN1; SMN2KDM4EATML3MBTL1ALDH1A1
SCHEMBL9581725 0.73 L3MBTL1 (0.55) AGTR2KDM4EATML3MBTL1ALDH1A1
Hydrochloric Acid SCHEMBL2858521 0.72 L3MBTL1 (0.54) SMN1; SMN2KDM4EATML3MBTL1ALDH1A1
SCHEMBL3654006 0.71 L3MBTL1 (0.56) AGTR2KDM4ETSHRATML3MBTL1
SCHEMBL14917669 0.71 AGTR2 (0.62) AGTR2KDM4EATML3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1670775-A4 PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS NEUROMED PHARMACEUTICALS LTD (CA) 2009-04-22 EP claimed
JP-2007504174-A 2007-03-01 JP claimed
EP-1670775-A1 PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS Neuromed Pharmaceuticals, Ltd. (CA) 2006-06-21 EP claimed
WO-2005021523-A1 PIPERAZINE SUBSTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS NEUROMED TECHNOLOGIES, INC. (CA) 2005-03-10 WO claimed