Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL792368 | 0.97 | TSHR (0.67) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| 1,2-Dichlorobenzene SCHEMBL27756839 | 0.91 | TSHR (0.59) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| 1,2-Dichlorobenzene SCHEMBL10452828 | 0.85 | TSHR (0.59) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| 1,2-Dichlorobenzene SCHEMBL11850148 | 0.83 | TSHR (0.91) | TSHRLMNAALDH1A1CYP2A6CES2 | |
| 1,2-Dichlorobenzene SCHEMBL28859926 | 0.81 | TSHR (0.62) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| 1,2-Dichlorobenzene SCHEMBL29177612 | 0.81 | TSHR (0.62) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| Chlorobenzene SCHEMBL231594 | 0.81 | TSHR (0.69) | TSHRLMNAALDH1A1TDP1HSD17B10 | |
| 1,2-Dichlorobenzene SCHEMBL28157020 | 0.79 | TSHR (0.83) | TSHRLMNAALDH1A1CYP2A6CES2 | |
| 1,2-Dichlorobenzene SCHEMBL5190 | 0.79 | — | — | |
| 1,2-Dichlorobenzene SCHEMBL1155123 | 0.79 | TSHR (1.00) | TSHRLMNAALDH1A1TDP1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601838-B2 | 2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2009-10-13 | — | — | US | disclosed |
| US-20070287723-A1 | 2-ALKYL/ARYL SULPHONYL-1,2,3,4-TETRAHYDRO-9H-PYRIDO (3,4-B) INDOLE-3-CARBOXYLIC ACID ESTERS/AMIDES USEFUL AS ANTITHROMBOTIC AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2007-12-13 | — | — | US | disclosed |
| WO-2006070385-A1 | 2-ALKYL/ARYL SULPHONYL-1,2,3,4-TETRAHYDRO-9H-PYRIDO (3,4-B) INDOLE-3-CARBOXYLIC ACID ESTERS/AMIDES USEFUL AS ANTITHROMBOTIC AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-07-06 | — | — | WO | disclosed |
| US-20060142322-A1 | 2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142322-A1 | 2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents | HTR3B, TH, IDO1 | TSHR 165/4885LMNA 3405/4885ALDH1A1 303/4885 |
| US-20070287723-A1 | 2-ALKYL/ARYL SULPHONYL-1,2,3,4-TETRAHYDRO-9H-PYRIDO (3,4-B) INDOLE-3-CARBOXYLIC ACID ESTERS/AMIDES USEFUL AS ANTITHROMBOTIC AGENTS | HTR3B, HTR3C, TH | TSHR 154/4885LMNA 3353/4885ALDH1A1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.