Sugi Predict

Sugi Predict / Compounds / 1,2-Dichlorobenzene

1,2-Dichlorobenzene

1,2-Dichlorobenzene

SCHEMBL792368

Clc1ccccc1Cl.O=S(=O)(Cl)Cl

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.67
▸ LMNA P02545 1/20 0.67
▸ ALDH1A1 P00352 5/20 0.48
▸ TDP1 Q9NUW8 2/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ CES2 O00748 1/20 0.43
▸ CES1 P23141 1/20 0.43
▸ IDO1 P14902 1/20 0.41
▸ DNMT1 P26358 1/20 0.41
▸ DNMT3L Q9UJW3 1/20 0.41
▸ DNMT3A Q9Y6K1 1/20 0.41
▸ CYP2A6 P11509 4/20 0.40
▸ CYP1A2 P05177 3/20 0.40
▸ HSD11B1 P28845 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ HTR6 P50406 1/20 0.38
▸ PTPRC P08575 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1,2-Dichlorobenzene SCHEMBL3864366 0.97 TSHR (0.62) TSHRLMNAALDH1A1TDP1HSD17B10
1,2-Dichlorobenzene SCHEMBL27756839 0.94 TSHR (0.59) TSHRLMNAALDH1A1TDP1HSD17B10
1,2-Dichlorobenzene SCHEMBL10452828 0.88 TSHR (0.59) TSHRLMNAALDH1A1TDP1HSD17B10
1,2-Dichlorobenzene SCHEMBL28859926 0.84 TSHR (0.62) TSHRLMNAALDH1A1TDP1HSD17B10
1,2-Dichlorobenzene SCHEMBL29177612 0.84 TSHR (0.62) TSHRLMNAALDH1A1TDP1HSD17B10
1,2-Dichlorobenzene SCHEMBL10593125 0.82 — —
1,2-Dichlorobenzene SCHEMBL1155123 0.82 TSHR (1.00) TSHRLMNAALDH1A1TDP1MEN1
1,2-Dichlorobenzene SCHEMBL29350623 0.82 — —
1,2-Dichlorobenzene SCHEMBL5190 0.82 — —
SCHEMBL9579955 0.81 TSHR (0.48) TSHRLMNAALDH1A1TDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1322708-A Preparation of di-tert-butyl dicarbonate YU BAIXING (CN) 2001-11-21 — — CN claimed
EP-2755963-B1 NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES HOFFMANN LA ROCHE (CH) 2019-10-30 — — EP disclosed
US-10125125-B2 N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors ACTIVE BIOTECH AB (SE) 2018-11-13 — — US disclosed
US-20180155330-A1 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS ACTIVE BIOTECH AB (SE) 2018-06-07 — — US disclosed
US-9873687-B2 N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors ACTIVE BIOTECH AB (SE) 2018-01-23 — — US disclosed
CN-103492028-B Sulfonaminoquinoline hepcidin antagonists 维福（国际）股份公司 2017-02-08 — — CN disclosed
CN-103012407-B N-[4-(1H-pyrazolo [3,4-b] pyrazine-6-base)-phenyl]-sulfonamides and the purposes as medicine thereof 赛诺菲 2016-06-29 — — CN disclosed
US-20160115158-A1 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS ACTIVE BIOTECH AB (SE) 2016-04-28 — — US disclosed
EP-2925743-B1 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS ACTIVE BIOTECH AB (SE) 2016-02-03 — — EP disclosed
CN-105283458-A Preparation of tert-butyl 4- ((1R,2S,5R) -6- (benzyloxy) -7-oxo-1, 6-diazabicyclo [3.2.1] octane-2-carboxamido) piperidine-1-carboxylate MERCK SHARP & DOHME 2016-01-27 — — CN disclosed
CN-1283189-A Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors DIMENSIONAL PHARM INC (US) 2001-02-07 — — CN disclosed
CN-1272107-A Benzamidine derivatives as factor Xa inhibitors MERCK PATENT GMBH (DE) 2000-11-01 — — CN disclosed
CN-1232451-A Substd. cyclic amine metalloprotease inhibitors PROCTER & GAMBLE (US) 1999-10-20 — — CN disclosed
CN-1215392-A Histamine H3 receptor ligands BLACK JAMES FOUNDATION (GB) 1999-04-28 — — CN disclosed
CN-1122597-A Intermediates and methods for the synthesis of anthrapyrazolone anticancer agents DU PONT MERCK PHARMA (US) 1996-05-15 — — CN disclosed
US-5026690-A Treating herpes simplex with sulfonamide derivatives; reduced side effects CHEMISCHE FABRIK STOCKHAUSEN GMBH (DE) 1991-06-25 — — US disclosed
US-4720580-A N-(aminoalkylene)benzenesulfonamides AMERICAN HOME PRODUCTS CORPORATION (US) 1988-01-19 — — US disclosed
EP-0167245-B1 ANTI-ARRHYTHMIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1987-06-16 — — EP disclosed
US-4618711-A Anti-arrhythmic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1986-10-21 — — US disclosed
EP-0167245-A1 Anti-arrhythmic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1986-01-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10125125-B2 N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors S100A9, S100B, S100A10 TSHR 3875/4885LMNA 691/4885ALDH1A1 4109/4885
US-20180155330-A1 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS S100A9, S100B, S100A10 TSHR 3875/4885LMNA 691/4885ALDH1A1 4109/4885
US-20160115158-A1 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS S100A9, S100A4, S100B TSHR 4024/4885LMNA 912/4885ALDH1A1 4370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.