Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2160831 | 0.98 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3HTR1AHTR6 | |
| SCHEMBL2944352 | 0.87 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3HTR1ASCD | |
| SCHEMBL3880092 | 0.87 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3HTR1ASCD | |
| Hydrochloric Acid SCHEMBL2949591 | 0.86 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3HTR1ASCD | |
| Tert-Butyl Formate SCHEMBL27792541 | 0.85 | SLC6A4 (0.40) | SLC6A4SLC6A2SLC6A3HTR1AHTR6 | |
| SCHEMBL13730861 | 0.84 | SCD (0.53) | SCD | |
| SCHEMBL473045 | 0.83 | HTR1A (0.51) | SLC6A2SLC6A3HTR1ASCDHTR2C | |
| SCHEMBL14957010 | 0.82 | SLC6A2 (0.60) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL3140594 | 0.82 | HTR1A (0.50) | SLC6A2SLC6A3HTR1ASCDHTR2C | |
| SCHEMBL14956969 | 0.79 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3HTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183958-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-07-28 | — | — | US | disclosed |
| US-20110183958-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-07-28 | — | — | US | disclosed |
| WO-2010043052-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2010-04-22 | — | — | WO | disclosed |
| CN-101641347-A | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme A delta-9 desaturase | MERCK FROSST CANADA LTD CA | 2010-02-03 | — | — | CN | disclosed |
| US-20090270434-A1 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | LEBLANC YVES | 2009-10-29 | — | — | US | disclosed |
| EP-2108015-A1 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Frosst Canada Ltd. (CA) | 2009-10-14 | — | — | EP | disclosed |
| US-7582633-B2 | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase | MERCK FROSST CANADA L.L.C. (CA) | 2009-09-01 | — | — | US | disclosed |
| US-20080182838-A1 | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase | MERCK CANADA INC. (CA) | 2008-07-31 | — | — | US | disclosed |
| WO-2008089580-A1 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182838-A1 | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase | SCD, SCD5, SREBF1 | SLC6A4 4787/4885SLC6A2 4782/4885SLC6A3 4753/4885 |
| US-20110183958-A1 | AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | SCD, SCD5, FADS2 | SLC6A4 3219/4885SLC6A2 2702/4885SLC6A3 2797/4885 |
| US-20090270434-A1 | AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | SCD, SCD5, SREBF1 | SLC6A4 4787/4885SLC6A2 4782/4885SLC6A3 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.