Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE8A | O60658 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | PDE6A | P16499 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090163 | 0.84 | HRH3 (0.53) | PPARGHRH3CYP3A4RXRACYP2D6 | |
| SCHEMBL5109146 | 0.79 | HRH3 (0.44) | PPARGHRH3CYP3A4RXRACYP2D6 | |
| SCHEMBL31601511 | 0.78 | PPARG (0.34) | PPARGHRH3CYP3A4RXRACYP2D6 | |
| SCHEMBL4140258 | 0.76 | CCR1 (0.41) | HRH3CYP2D6CYP1A2NPC1POLB | |
| SCHEMBL3916037 | 0.76 | NPC1 (0.40) | NPC1POLBRAB9APDE1B | |
| SCHEMBL23525243 | 0.76 | HRH3 (0.37) | HRH3CYP2D6CYP1A2HTR2C | |
| SCHEMBL6705826 | 0.76 | HRH1 (0.44) | HRH3CYP2D6CYP1A2ADRB2ADRA1A | |
| SCHEMBL6935097 | 0.76 | CCR1 (0.41) | PDE4DPDE2APDE8APDE5APDE9A | |
| SCHEMBL1844682 | 0.75 | ACACB (0.45) | HRH3NPC1POLBRAB9ACBFB | |
| SCHEMBL22293298 | 0.75 | HRH3 (0.34) | PPARGHRH3RXRACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598382-B2 | Aryl substituted imidazoquinolines | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-7091214-B2 | Aryl substituted Imidazoquinolines | 3M INNOVATIVE PROPERTIES CO. (US) | 2006-08-15 | — | — | US | disclosed |