Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38651000 | 0.85 | STAT3 (0.55) | STAT3ALDH1A1ACE2HDAC4HDAC1 | |
| SCHEMBL38651123 | 0.82 | STAT3 (0.61) | STAT3ALDH1A1HDAC4HDAC1 | |
| SCHEMBL12640087 | 0.81 | STAT3 (0.75) | STAT3ALDH1A1BCL2MCL1KMT2A | |
| Napabucasin SCHEMBL29349770 | 0.81 | STAT3 (1.00) | STAT3ALDH1A1BCL2MCL1KMT2A | |
| Napabucasin SCHEMBL1883845 | 0.81 | STAT3 (1.00) | STAT3ALDH1A1BCL2MCL1KMT2A | |
| SCHEMBL18691843 | 0.80 | STAT3 (0.73) | STAT3ALDH1A1BCL2MCL1KMT2A | |
| SCHEMBL12640086 | 0.80 | STAT3 (0.73) | STAT3ALDH1A1BCL2MCL1KMT2A | |
| SCHEMBL38651118 | 0.79 | HDAC1 (0.60) | STAT3ALDH1A1HDAC4HDAC1 | |
| SCHEMBL38650973 | 0.79 | HDAC1 (0.61) | STAT3ALDH1A1HDAC4HDAC1 | |
| SCHEMBL38651008 | 0.79 | HDAC1 (0.61) | STAT3ALDH1A1HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122010883-A | Napabucasin derivative with double-target anti-tumor activity and preparation method and application thereof | 中国海洋大学 | 2026-05-12 | — | — | CN | claimed |
| CN-122010883-A | Napabucasin derivative with double-target anti-tumor activity and preparation method and application thereof | 中国海洋大学 | 2026-05-12 | — | — | CN | disclosed |