Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Napabucasin SCHEMBL29349770 | 1.00 | STAT3 (1.00) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL19597404 | 0.89 | STAT3 (0.79) | STAT3ALDH1A1MAPTHTTLMNA | |
| Napabucasin SCHEMBL3654300 | 0.88 | STAT3 (0.78) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL16917433 | 0.86 | STAT3 (0.76) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL12640087 | 0.86 | STAT3 (0.75) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL12494612 | 0.85 | STAT3 (0.73) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL12640086 | 0.84 | STAT3 (0.73) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL18691843 | 0.84 | STAT3 (0.73) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL29364489 | 0.83 | STAT3 (0.71) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL29362059 | 0.83 | STAT3 (0.71) | STAT3ALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11414394-B2 | Process for producing a hydrate of a hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid | SUMITOMO PHARMA ONCOLOGY, INC. (US) | 2022-08-16 | — | — | US | claimed |
| US-20210115006-A1 | NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2021-04-22 | — | — | US | claimed |
| US-20210070724-A1 | METHOD FOR PRODUCING 2-ACETYL-4H,9H-NAPHTHO[2,3-B]FURAN-4,9-DIONE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-03-11 | — | — | US | claimed |
| CN-105963289-B | STAT3 pathway inhibitor and cancer stem cell pathway inhibitor | 北京强新生物科技有限公司 | 2021-02-26 | — | — | CN | claimed |
| EP-3067054-B1 | NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT | BOSTON BIOMEDICAL INC (US) | 2020-12-30 | — | — | EP | claimed |
| US-10875835-B2 | Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-12-29 | — | — | US | claimed |
| US-20200392098-A1 | SUBSTITUTED NAPHTHO[2,3-b]FURANS AS WATER-SOLUBLE PRODRUGS FOR PREVENTING AND/OR TREATING CANCER | BOSTON BIOMEDICAL, INC. (US) | 2020-12-17 | — | — | US | claimed |
| US-20200237711-A1 | Compositions for Treating and/or Preventing Cancer | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. | 2020-07-30 | — | — | US | claimed |
| US-20200190049-A1 | METHOD FOR PRODUCING 2-ACETYL-4H,9H-NAPHTHO[2,3-B]FURAN-4,9-DIONE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-06-18 | — | — | US | claimed |
| US-10611746-B2 | Method for producing 2-acetyl-4H,9H-naphtho[2,3-B]furan-4,9-dione | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-04-07 | — | — | US | claimed |
| WO-2012119265-A1 | NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2012-09-13 | — | — | WO | claimed |
| US-20110112180-A1 | NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS | BOSTON BIOMEDICAL, INC. (US) | 2011-05-12 | — | — | US | claimed |
| US-20100310503-A1 | NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. | 2010-12-09 | — | — | US | claimed |
| EP-2200431-A1 | NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT | Boston Biomedical, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| EP-2194987-A2 | NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS | Boston Biomedical, Inc. (US) | 2010-06-16 | — | — | EP | claimed |
| EP-2190429-A1 | A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | Boston Biomedical, Inc. (US) | 2010-06-02 | — | — | EP | claimed |
| WO-2009036099-A1 | A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | BOSTON BIOMEDICAL, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| WO-2009036101-A1 | NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT | BOSTON BIOMEDICAL, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| WO-2009036059-A2 | NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS | BOSTON BIOMEDICAL, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-1134216-B1 | ANTI-DRUG RESISTANT STRAIN AGENTS AND ANTICHLAMYDIA AGENTS | JAPAN SCIENCE & TECH CORP (JP) | 2004-05-06 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11414394-B2 | Process for producing a hydrate of a hydrochloride salt of 2,2′-((((((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid | ADH1A, ADH1C, DACH1 | STAT3 1555/4885ALDH1A1 180/4885MAPT 1047/4885 |
| US-20200392098-A1 | SUBSTITUTED NAPHTHO[2,3-b]FURANS AS WATER-SOLUBLE PRODRUGS FOR PREVENTING AND/OR TREATING CANCER | NR0B1, NR0B2, NR2C2 | STAT3 2147/4885ALDH1A1 716/4885MAPT 4840/4885 |
| US-10875835-B2 | Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione | ADH1A, ADH1C, NQO1 | STAT3 3989/4885ALDH1A1 52/4885MAPT 2680/4885 |
| US-20110112180-A1 | NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS | STAT3, STAT1, STAT5B | STAT3 1/4885ALDH1A1 630/4885MAPT 4328/4885 |
| US-10611746-B2 | Method for producing 2-acetyl-4H,9H-naphtho[2,3-B]furan-4,9-dione | ADH1A, ADH1C, NQO1 | STAT3 3989/4885ALDH1A1 52/4885MAPT 2680/4885 |
| US-20200190049-A1 | METHOD FOR PRODUCING 2-ACETYL-4H,9H-NAPHTHO[2,3-B]FURAN-4,9-DIONE | ADH1A, ADH1C, NQO1 | STAT3 3989/4885ALDH1A1 52/4885MAPT 2680/4885 |
| US-20210070724-A1 | METHOD FOR PRODUCING 2-ACETYL-4H,9H-NAPHTHO[2,3-B]FURAN-4,9-DIONE | ADH1A, ADH1C, NQO1 | STAT3 3989/4885ALDH1A1 52/4885MAPT 2680/4885 |
| US-20200237711-A1 | Compositions for Treating and/or Preventing Cancer | SLC33A1, SLCO2B1, SLCO1B1 | STAT3 2236/4885ALDH1A1 143/4885MAPT 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.