SCHEMBL38656117

SCHEMBL38656117

Nc1ccc(C2(C(F)(F)F)CC2)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.41
BACE1 P56817 9/20 0.35
BACE2 Q9Y5Z0 5/20 0.35
TSHR P16473 2/20 0.34
GLA P06280 1/20 0.34
POLB P06746 1/20 0.34
GAA P10253 1/20 0.34
KIF11 P52732 1/20 0.33
MAPK1 P28482 2/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
GFER P55789 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6609077 0.84 BACE1 (0.34) PDK2BACE1BACE2MAPK1ALDH1A1
SCHEMBL23206456 0.80 ALDH1A1 (0.42) PDK2BACE1BACE2TSHRGLA
SCHEMBL12983307 0.73 PDK2 (0.40) PDK2BACE1BACE2GAAMAPK1
SCHEMBL38655265 0.73 PDK2 (0.47) PDK2POLBMAPK1ALDH1A1LMNA
SCHEMBL16764551 0.70 ALDH1A1 (0.45) PDK2KIF11ALDH1A1LMNAMAPT
Hydrochloric Acid SCHEMBL32670447 0.68 ALDH1A1 (0.43) KIF11ALDH1A1LMNAMAPTTDP1
SCHEMBL30212897 0.68 TSHR (0.44) PDK2TSHRGLAPOLBGAA
SCHEMBL24028220 0.68 TSHR (0.44) PDK2TSHRGLAPOLBGAA
SCHEMBL38657142 0.68
SCHEMBL21543374 0.67 PDK2 (0.43) PDK2GAAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026102082-A1 ALKYLPHENYL SUBSTITUTED COMPOUNDS, COMPOSITIONS AND METHODS OF USE DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use GIPR, MC2R, GRPR PDK2 2899/4885BACE1 4082/4885BACE2 3350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.