Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839194 | 0.96 | L3MBTL1 (0.40) | CNR1CNR2CYP4F2CYP4A11PTGES | |
| SCHEMBL3836753 | 0.88 | PTGES (0.47) | PTGESKDM4EPOLBMTNR1AMTNR1B | |
| SCHEMBL611662 | 0.88 | FFAR1 (0.49) | CNR1PTGESKDM4EPOLBL3MBTL1 | |
| SCHEMBL3863964 | 0.86 | PTGES (0.48) | PTGESKDM4EPOLBMTNR1AMTNR1B | |
| SCHEMBL610995 | 0.86 | KDM4E (0.44) | KDM4EPOLBMTNR1AMTNR1BFFAR1 | |
| SCHEMBL3865432 | 0.85 | KDM4E (0.45) | KDM4EPOLBMTNR1AMTNR1BFFAR1 | |
| SCHEMBL3837675 | 0.84 | L3MBTL1 (0.42) | PTGESKDM4EPOLBL3MBTL1MTNR1A | |
| SCHEMBL236269 | 0.83 | TDP1 (0.48) | HTR2CHTR2BCYP4F2CYP4A11PTGES | |
| SCHEMBL3843278 | 0.83 | PTGES (0.54) | PTGESKDM4EPOLBL3MBTL1FFAR1 | |
| SCHEMBL610894 | 0.80 | TDP1 (0.46) | PTGESMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |