Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862235 | 1.00 | HAO1 (0.38) | HAO1FFAR1FFAR4KCNH2PTGES | |
| SCHEMBL3860383 | 1.00 | HAO1 (0.38) | HAO1FFAR1FFAR4KCNH2PTGES | |
| SCHEMBL3860142 | 0.99 | HAO1 (0.37) | HAO1FFAR1FFAR4KCNH2PTGES | |
| SCHEMBL3862593 | 0.93 | PTGES (0.38) | HAO1FFAR1PTGESBACE1GRM5 | |
| SCHEMBL14576175 | 0.82 | GRM5 (0.32) | GRM5CFDTPSB2 | |
| SCHEMBL3862437 | 0.81 | HAO1 (0.41) | HAO1PAX8GRM5CFDTPSB2 | |
| SCHEMBL235715 | 0.80 | HAO1 (0.38) | HAO1FFAR1FFAR4KCNH2PTGES | |
| SCHEMBL233546 | 0.80 | HAO1 (0.38) | HAO1FFAR1FFAR4KCNH2PTGES | |
| SCHEMBL233144 | 0.80 | HAO1 (0.38) | HAO1FFAR1FFAR4KCNH2PTGES | |
| SCHEMBL3860996 | 0.78 | KCNH2 (0.41) | HAO1FFAR1FFAR4KCNH2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |