Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870016 | 0.84 | CFD (0.35) | HAO1NPC1RAB9AL3MBTL1CFD | |
| SCHEMBL3859911 | 0.83 | CFD (0.34) | HAO1NPC1RAB9AL3MBTL1CFD | |
| SCHEMBL3860142 | 0.82 | HAO1 (0.37) | HAO1CFDTPSB2PAX8GRM5 | |
| SCHEMBL3862235 | 0.81 | HAO1 (0.38) | HAO1CFDTPSB2PAX8GRM5 | |
| SCHEMBL3865992 | 0.81 | HAO1 (0.38) | HAO1CFDTPSB2PAX8GRM5 | |
| SCHEMBL3860383 | 0.81 | HAO1 (0.38) | HAO1CFDTPSB2PAX8GRM5 | |
| SCHEMBL233645 | 0.80 | HAO1 (0.41) | HAO1NPC1RAB9AL3MBTL1 | |
| SCHEMBL3862593 | 0.79 | PTGES (0.38) | HAO1CFDTPSB2HTR2CHTR2B | |
| SCHEMBL3867999 | 0.77 | CFD (0.44) | CFDTPSB2 | |
| SCHEMBL3870082 | 0.76 | HTR2A (0.46) | HAO1CFDTPSB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |