Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 2/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.64 |
| ▸ | SHBG | P04278 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 11/20 | 0.63 |
| ▸ | STS | P08842 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870740 | 0.98 | KMT2A (0.68) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3864661 | 0.98 | KMT2A (0.68) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3876321 | 0.95 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3870726 | 0.93 | ESR1 (0.69) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3871356 | 0.92 | CA2 (0.73) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3868065 | 0.90 | MAPT (0.66) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3300046 | 0.89 | LMNA (0.80) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3870706 | 0.89 | CA2 (0.58) | SMN1; SMN2CYP3A4MAPTTP53ESR1 | |
| SCHEMBL3872155 | 0.87 | CA2 (0.66) | CYP3A4MAPTTP53ESR1KMT2A | |
| SCHEMBL3864673 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP3A4MAPTTP53ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534780-B2 | Estradiol prodrugs | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-05-19 | — | — | US | claimed |
| US-20050288267-A1 | Estradiol prodrugs | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-12-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288267-A1 | Estradiol prodrugs | CYP19A1, ESR1, HSD17B11 | SMN1; SMN2 4715/4885CYP3A4 23/4885MAPT 3210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.