Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778864 | 0.87 | AURKA (0.41) | GRM4PIM1ADORA3GRM1NPSR1 | |
| SCHEMBL3866786 | 0.85 | KDM4E (0.48) | MEN1KMT2ANPSR1NPC1ALDH1A1 | |
| SCHEMBL3866073 | 0.83 | HPGD (0.42) | ADORA3MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL3869683 | 0.83 | FGFR4 (0.40) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3872653 | 0.83 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1TP53HPGD | |
| SCHEMBL3870804 | 0.83 | NPC1 (0.45) | MEN1KMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3868202 | 0.83 | NPSR1 (0.41) | MEN1KMT2ANPSR1ALDH1A1HPGD | |
| SCHEMBL3866586 | 0.83 | POLB (0.42) | MEN1KMT2ASMN1; SMN2NPSR1NPC1 | |
| SCHEMBL3869847 | 0.82 | MAPK1 (0.49) | MEN1KMT2ASMN1; SMN2NPSR1NPC1 | |
| SCHEMBL4633630 | 0.81 | CA1 (0.48) | GRM4ADORA3MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904503-B1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-11-06 | — | — | EP | disclosed |
| US-20090149457-A1 | 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-06-11 | — | — | US | disclosed |
| EP-1904503-A1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007009898-A1 | 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149457-A1 | 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors | CCNH, PDK1, MAP3K5 | GRM4 2485/4885PIM1 230/4885ADORA3 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.